Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LA_2011Response regulator containing a signal receiver domain and a DNA/RNA polymerase-binding domain. (240 aa)    
Predicted Functional Partners:
LA_2012
Sensory histidine kinase CreC.
 
  0.994
LA_2421
Histidine kinase sensor protein.
 
 
 0.872
LA_0289
Adenylate/guanylate cyclase.
  
 
 0.853
LA_2541
Histidine kinase response regulator hybrid protein.
 
 
 0.842
vicK
Two-component sensor histidine kinase VicK.
 
 
 0.837
LB_322
Histidine kinase sensor protein.
 
 
 0.830
baeS
Signal transduction histidine kinase.
  
   0.818
LA_2805
Histidine kinase sensor protein.
 
 
 0.816
LA_2951
Two-component hybrid sensor and regulator.
  
 
 0.789
LB_014
Sensor protein of a two component response regulator.
  
   0.773
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.