node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LA_2060 | met17 | LA_2060 | LA_2062 | Putative methyltransferase. | O-acetylhomoserine/O-acetylserine sulfhydrylase. | 0.419 |
LA_2060 | met2 | LA_2060 | LA_2061 | Putative methyltransferase. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | 0.994 |
glyA | met2 | LA_1409 | LA_2061 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | 0.926 |
glyA | metH | LA_1409 | LB_108 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.936 |
glyA | pssA | LA_1409 | LA_1451 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
glyA | serB | LA_1409 | LA_2145 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase. | 0.926 |
glyA | trpA | LA_1409 | LA_3288 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.935 |
glyA | trpB | LA_1409 | LA_3289 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.938 |
met17 | LA_2060 | LA_2062 | LA_2060 | O-acetylhomoserine/O-acetylserine sulfhydrylase. | Putative methyltransferase. | 0.419 |
met17 | met2 | LA_2062 | LA_2061 | O-acetylhomoserine/O-acetylserine sulfhydrylase. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | 0.995 |
met17 | metC | LA_2062 | LA_0113 | O-acetylhomoserine/O-acetylserine sulfhydrylase. | Cystathionine gamma-synthase. | 0.952 |
met17 | metH | LA_2062 | LB_108 | O-acetylhomoserine/O-acetylserine sulfhydrylase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.964 |
met17 | thrA | LA_2062 | LA_3638 | O-acetylhomoserine/O-acetylserine sulfhydrylase. | Homoserine dehydrogenase. | 0.874 |
met2 | LA_2060 | LA_2061 | LA_2060 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | Putative methyltransferase. | 0.994 |
met2 | glyA | LA_2061 | LA_1409 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
met2 | met17 | LA_2061 | LA_2062 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | O-acetylhomoserine/O-acetylserine sulfhydrylase. | 0.995 |
met2 | metC | LA_2061 | LA_0113 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine gamma-synthase. | 0.946 |
met2 | metH | LA_2061 | LB_108 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.818 |
met2 | pssA | LA_2061 | LA_1451 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | CDP-diacylglycerol--serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.800 |
met2 | serB | LA_2061 | LA_2145 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family. | Phosphoserine phosphatase. | 0.807 |