serB protein (Leptospira interrogans) - STRING interaction network

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Score

serB

Phosphoserine phosphatase. (293 aa)

Predicted Functional Partners:

serC

0.947

glyA

0.929

trpB

0.921

pssA

0.905

trpA

0.902

LA_2144

0.860

cysE

0.815

cysE-2

0.815

met2

0.805

hisF

0.799

Your Current Organism:

Leptospira interrogans

NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LA_2144	serB	LA_2144	LA_2145	SGNH-hydrolase.	Phosphoserine phosphatase.	0.860
cysE	cysE-2	LA_0062	LA_1821	Serine acetyltransferase.	Serine acetyltransferase.	0.927
cysE	glyA	LA_0062	LA_1409	Serine acetyltransferase.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.814
cysE	pssA	LA_0062	LA_1451	Serine acetyltransferase.	CDP-diacylglycerol--serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.801
cysE	serB	LA_0062	LA_2145	Serine acetyltransferase.	Phosphoserine phosphatase.	0.815
cysE	trpA	LA_0062	LA_3288	Serine acetyltransferase.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.804
cysE	trpB	LA_0062	LA_3289	Serine acetyltransferase.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.804
cysE-2	cysE	LA_1821	LA_0062	Serine acetyltransferase.	Serine acetyltransferase.	0.927
cysE-2	glyA	LA_1821	LA_1409	Serine acetyltransferase.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.814
cysE-2	pssA	LA_1821	LA_1451	Serine acetyltransferase.	CDP-diacylglycerol--serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.801
cysE-2	serB	LA_1821	LA_2145	Serine acetyltransferase.	Phosphoserine phosphatase.	0.815
cysE-2	trpA	LA_1821	LA_3288	Serine acetyltransferase.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.804
cysE-2	trpB	LA_1821	LA_3289	Serine acetyltransferase.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.804
glyA	cysE	LA_1409	LA_0062	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Serine acetyltransferase.	0.814
glyA	cysE-2	LA_1409	LA_1821	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Serine acetyltransferase.	0.814
glyA	met2	LA_1409	LA_2061	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Belongs to the AB hydrolase superfamily. MetX family.	0.926
glyA	pssA	LA_1409	LA_1451	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	CDP-diacylglycerol--serine O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.900
glyA	serB	LA_1409	LA_2145	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoserine phosphatase.	0.929
glyA	serC	LA_1409	LA_0366	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	0.723
glyA	trpA	LA_1409	LA_3288	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.933