Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LA_2164acyl-CoA hydrolase. (140 aa)    
Predicted Functional Partners:
prfB
peptidyl-tRNA hydrolase involved in peptide chain release.
  
   0.883
rpmB
50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.
  
    0.880
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
       0.860
LA_2160
Hypothetical protein.
       0.697
paaJ
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.650
paaJ-3
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.650
LA_4139
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.650
nemA
2,4-dienoyl-CoA reductase (NADPH).
      
 0.632
paaJ-2
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.603
sdhA
Succinate dehydrogenase flavoprotein subunit.
      
 0.590
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
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