Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tldD-2Predicted Zn-dependent protease. (444 aa)    
Predicted Functional Partners:
tldD
Predicted Zn-dependent protease.
 
    
0.901
scpA
Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
     
 0.739
LA_2182
HIT family hydrolase.
       0.709
LA_2183
Hypothetical protein.
       0.618
pbpC
Penicillin binding protein.
       0.600
LA_2188
ATPase.
       0.568
LA_2189
Conserved hypothetical protein.
       0.568
LA_2186
Hypothetical protein.
       0.565
LA_1955
Predicted hydrolase of the alpha/beta-hydrolase.
 
   
 0.500
clpP
ATP-dependent protease ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
     
 0.437
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
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