Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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spoTGuanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (674 aa)    
Predicted Functional Partners:
gmk
Guanylate kinase.
  
 
 0.944
ppx
Exopolyphosphatase.
  
 
 0.940
mazG
Nucleoside triphosphate pyrophosphohydrolase MazG.
  
 
 0.931
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.918
cyaA-9
Adenylate/guanylate cyclase.
    
 0.906
cyaA-3
Adenylate/guanylate cyclase.
     
 0.905
nrdA
Ribonucleotide reductase subunit alpha; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen (By similarity).
   
 
  0.903
LA_2536
Adenylate/guanylate cyclase.
     
 0.903
rplI
50S ribosomal protein L9; Binds to the 23S rRNA.
  
 
   0.901
LA_0288
Adenylate/guanylate cyclase.
     
  0.900
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
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