Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LA_3207Histidine kinase sensor protein. (1165 aa)    
Predicted Functional Partners:
LA_1745
Histidine kinase and response regulator hybrid protein.
  
 
 0.963
LA_3206
Two-component response regulator receiver protein.
 
 
 
 0.952
LA_3858
Histidine kinase and response regulator hybrid protein.
 
 
 0.934
LA_2541
Histidine kinase response regulator hybrid protein.
 
 
 0.854
LA_0289
Adenylate/guanylate cyclase.
  
 
 0.847
LA_2222
Sensor histidine kinase and response regulator of a two component complex.
 
 
 
0.838
LA_1528
Two-component response regulator.
 
 
 0.836
LA_1432
Two-component response regulator receiver protein.
 
 
 0.830
LA_3514
Serine/threonine phosphatase containing signal receiver domain REC.
 
 
 
 0.806
LA_1186
Two-component response regulator.
 
 
 0.802
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.