STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdlB-2ATPase and permease components of ABC-type multidrug transport system. (606 aa)    
Predicted Functional Partners:
sunT
ABC transporter ATP-binding protein.
 
 
 
0.795
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
  
 0.795
pabA
Anthranilate synthase component II.
   
 
 0.782
LA_3631
Receiver component of a two-component response regulator.
       0.773
caiA-6
acyl-CoA dehydrogenase.
  
   0.717
dnaK
DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.713
LA_1470
Hypothetical protein.
  
 0.696
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
 
   0.616
fabG-2
Short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.561
spoVK
AAA family ATPase.
  
 
  0.532
Your Current Organism:
Leptospira interrogans
NCBI taxonomy Id: 189518
Other names: L. interrogans serovar Lai str. 56601, Leptospira interrogans serovar Lai str. 56601
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.