node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mkms_1185 | Mkms_2857 | Mkms_1185 | Mkms_2857 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | 0.959 |
Mkms_1185 | Mkms_3917 | Mkms_1185 | Mkms_3917 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.927 |
Mkms_1185 | Mkms_4330 | Mkms_1185 | Mkms_4330 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mmc:Mmcs_4244 MazG nucleotide pyrophosphohydrolase. | 0.905 |
Mkms_1185 | Mkms_4861 | Mkms_1185 | Mkms_4861 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | KEGG: mmc:Mmcs_4775 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.913 |
Mkms_1185 | guaA | Mkms_1185 | Mkms_1190 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.996 |
Mkms_1185 | guaB | Mkms_1185 | Mkms_1184 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.985 |
Mkms_1185 | pheT | Mkms_1185 | Mkms_3017 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: mmc:Mmcs_2973 phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.744 |
Mkms_1185 | purA | Mkms_1185 | Mkms_0526 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.976 |
Mkms_1185 | purH | Mkms_1185 | Mkms_4405 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | IMP cyclohydrolase; KEGG: mmc:Mmcs_4319 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.949 |
Mkms_1185 | rpoZ | Mkms_1185 | Mkms_2418 | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.751 |
Mkms_2857 | Mkms_1185 | Mkms_2857 | Mkms_1185 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | 0.959 |
Mkms_2857 | Mkms_3917 | Mkms_2857 | Mkms_3917 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.935 |
Mkms_2857 | Mkms_4330 | Mkms_2857 | Mkms_4330 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mmc:Mmcs_4244 MazG nucleotide pyrophosphohydrolase. | 0.905 |
Mkms_2857 | Mkms_4861 | Mkms_2857 | Mkms_4861 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | KEGG: mmc:Mmcs_4775 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.930 |
Mkms_2857 | guaA | Mkms_2857 | Mkms_1190 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.997 |
Mkms_2857 | guaB | Mkms_2857 | Mkms_1184 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.929 |
Mkms_2857 | pheT | Mkms_2857 | Mkms_3017 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: mmc:Mmcs_2973 phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.744 |
Mkms_2857 | purA | Mkms_2857 | Mkms_0526 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.976 |
Mkms_2857 | purH | Mkms_2857 | Mkms_4405 | KEGG: mmc:Mmcs_2813 IMP dehydrogenase related 1; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase. | IMP cyclohydrolase; KEGG: mmc:Mmcs_4319 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.945 |
Mkms_3917 | Mkms_1185 | Mkms_3917 | Mkms_1185 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | TIGRFAM: IMP dehydrogenase family protein; KEGG: mmc:Mmcs_1168 IMP dehydrogenase related 2. | 0.927 |