STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mkms_5004KEGG: mmc:Mmcs_4915 hypothetical protein. (347 aa)    
Predicted Functional Partners:
Mkms_5005
PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mmc:Mmcs_4916 ATP dependent DNA ligase.
   
 0.990
Mkms_5027
PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: mmc:Mmcs_4939 ATP dependent DNA ligase.
   
 0.977
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.917
Mkms_0854
KEGG: nfa:nfa29400 putative ATP-dependent DNA ligase.
   
 0.797
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.732
Mkms_5006
PFAM: HNH endonuclease; protein of unknown function DUF222; SMART: HNH nuclease; KEGG: mmc:Mmcs_4917 protein of unknown function DUF222.
       0.634
Mkms_4422
DNA-formamidopyrimidine glycosylase; PFAM: Formamidopyrimidine-DNA glycolase; KEGG: mmc:Mmcs_4336 DNA-formamidopyrimidine glycosylase; Belongs to the FPG family.
 
   
 0.469
Mkms_5007
PFAM: regulatory protein, TetR; KEGG: mmc:Mmcs_4918 transcriptional regulator, TetR family.
       0.427
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
      
 0.404
Your Current Organism:
Mycobacterium sp. KMS
NCBI taxonomy Id: 189918
Other names: M. sp. KMS
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.