STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pcbCPenicillin synthase; Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin. (329 aa)    
Predicted Functional Partners:
pcbAB
Non-ribosomal peptide synthetase; Each of the constituent amino acids of ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates; Belongs to the ATP-dependent AMP-binding enzyme family.
    
 0.988
cefD
Penicillin epimerase; Catalyzes the reversible isomerization between isopenicillin N and penicillin N; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
     
 0.944
ANW20436.1
Peptidase C45; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.914
lat
L-lysine 6-transaminase; Catalyzes the transfer of the terminal amino group of L- lysine or L-ornithine to alpha-ketoglutarate. Oxaloacetate and pyruvate can also be used as acceptors of the amino group but with very low efficiency.
  
  
 0.716
ANW21549.1
Tungsten formylmethanofuran dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.685
cmcJ
7-alpha-cephem-methoxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.615
cmcI
Cephalosporin hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.580
cmcH
3-hydroxymethylcephem carbamoyltransferase; Catalyzes the carbamoylation reaction in the cephamycin biosynthesis; Belongs to the NodU/CmcH family.
      
 0.463
cefE
Cephalosporin hydroxylase; Catalyzes the step from penicillin N to deacetoxy- cephalosporin C.
  
   
0.454
cefF
Cephalosporin hydroxylase; Hydroxylation of desacetoxicephalosporin C in 3'position to form deacetylcephalosporin C.
  
   
0.427
Your Current Organism:
Streptomyces clavuligerus
NCBI taxonomy Id: 1901
Other names: ATCC 27064, BCRC 11518, CBS 226.75, CCRC 11518, CCRC:11518, CECT 3125, DSM 40751, DSM 738, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, NCIMB 14335, NRRL 3585, S. clavuligerus, Streptomyces clavuligerus ATCC 27064, Streptomyces clavuligerus NRRL 3585, VKM Ac-602
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.