Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pahAgmatinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (313 aa)    
Predicted Functional Partners:
cs2
Clavaminate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.980
cs1
Clavaminate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.936
bls
Asparagine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the asparagine synthetase family.
  
  
 0.733
ceaS
Decarboxylase; Involved in the biosynthesis of the beta-lactamase inhibitor, clavulanic acid. Catalyzes the thiamine diphosphate (ThDP) dependent condensation of D-glyceraldehyde-3-phosphate (D-G3P) with L-arginine to yield the beta-amino acid, N2-(2-carboxyethyl)arginine (CEA) via a beta-elimination resulting in the formation of an enol which undergoes a second elimination to generate the alpha,beta-unsaturated acryloyl- ThDP; Belongs to the TPP enzyme family.
  
  
 0.723
leuS
leucine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family.
    
   0.603
ANW17758.1
Hybrid sensor histidine kinase/response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.558
argJ3
Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
     
 0.511
ANW16950.1
Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.510
hutH2
Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.510
hutH1
Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.510
Your Current Organism:
Streptomyces clavuligerus
NCBI taxonomy Id: 1901
Other names: ATCC 27064, BCRC 11518, CBS 226.75, CCRC 11518, CCRC:11518, CECT 3125, DSM 40751, DSM 738, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, NCIMB 14335, NRRL 3585, S. clavuligerus, Streptomyces clavuligerus ATCC 27064, Streptomyces clavuligerus NRRL 3585, VKM Ac-602
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