STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmg1Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (410 aa)    
Predicted Functional Partners:
pksG
3-hydroxy-3-methylglutaryl CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.999
erg12
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 0.983
tldD
Predicted Zn-dependent protease of TldD family.
      
 0.875
ispA
Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.795
mtd
F420 dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT; Belongs to the MTD family.
      
 0.733
MK1378
Acetyl-CoA acetyltransferase.
  
  
 0.733
MK0486
ATPase of the AAA+ class.
    
 
 0.720
pyrF
Orotidine-5'-phosphate decarboxylase.
     
 0.590
lldD
L-lactate dehydrogenase (FMN-dependent); Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
     
 0.585
trpE
Anthranilate/para-aminobenzoate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismat [...]
     
 0.579
Your Current Organism:
Methanopyrus kandleri
NCBI taxonomy Id: 190192
Other names: M. kandleri AV19, Methanopyrus kandleri AV19, Methanopyrus kandleri str. AV19
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