STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
purQPhosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with P [...] (230 aa)    
Predicted Functional Partners:
BTN85_0161
Phosphoribosylformylglycinamidine (FGAM) synthase PurS component; arCOG04462; gene: purS.
 
 0.999
purM
Phosphoribosylaminoimidazole (AIR) synthetase PurM; arCOG00639; gene: purM.
 
 0.999
purL
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and [...]
 0.999
BTN85_1816
Phosphoribosylamine-glycine ligase PurD; arCOG04415; gene: purD.
 
 0.998
purF
Glutamine phosphoribosylpyrophosphate amidotransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.997
BTN85_1965
AICAR transformylase/IMP cyclohydrolase PurH; arCOG02824; gene: purH.
  
 
 0.996
purE
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
 
 0.995
purC
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase PurC; arCOG04421; gene: purC; Belongs to the SAICAR synthetase family.
  
 
 0.994
BTN85_0466
Adenylosuccinate lyase PurB; arCOG01747; gene: purB; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.978
carA
Carbamoylphosphate synthase small subunit CarA; arCOG00064; gene: carA; Belongs to the CarA family.
  
 
 0.876
Your Current Organism:
Methanohalarchaeum thermophilum
NCBI taxonomy Id: 1903181
Other names: C. Methanohalarchaeum thermophilum, Candidatus Methanohalarchaeum thermophilum, Euryarchaeota archaeon HMET1, archaeon HMET1, strain HMET1
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