STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase PurB; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (337 aa)    
Predicted Functional Partners:
BTN85_0466
Adenylosuccinate lyase PurB; arCOG01747; gene: purB; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 0.999
BTN85_1965
AICAR transformylase/IMP cyclohydrolase PurH; arCOG02824; gene: purH.
  
 0.977
purC
Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase PurC; arCOG04421; gene: purC; Belongs to the SAICAR synthetase family.
  
 0.937
purF
Glutamine phosphoribosylpyrophosphate amidotransferase PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.937
glyA
Glycine/serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.927
rpl11
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family.
  
  
 0.922
rpl3
Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
  
  
 0.910
pyrG
CTP synthase (UTP-ammonia lyase) PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
 
 0.908
BTN85_1816
Phosphoribosylamine-glycine ligase PurD; arCOG04415; gene: purD.
  
 
 0.904
purL
Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and [...]
  
  
 0.902
Your Current Organism:
Methanohalarchaeum thermophilum
NCBI taxonomy Id: 1903181
Other names: C. Methanohalarchaeum thermophilum, Candidatus Methanohalarchaeum thermophilum, Euryarchaeota archaeon HMET1, archaeon HMET1, strain HMET1
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