STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BTN85_03033-hydroxy-3-methylglutaryl CoA synthase; arCOG01767; gene: pksG; Belongs to the thiolase-like superfamily. UPF0219 family. (345 aa)    
Predicted Functional Partners:
BTN85_0300
Hydroxymethylglutaryl-CoA reductase HMG1; arCOG04260; gene: HMG1; Belongs to the HMG-CoA reductase family.
 
 
 0.999
BTN85_0301
OB-fold domain and Zn-ribbon containing protein putative acyl-CoA-binding protein; arCOG01285.
 
 0.999
BTN85_0302
Acetyl-CoA acetyltransferase; arCOG01278; gene: paaJ.
 
 0.999
BTN85_0304
Putative transcriptional regulator; arCOG04060.
  
    0.957
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 
 0.933
fni
Type II isopentenyl diphosphate isomerase Idi; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
 
 0.895
BTN85_0071
Pyruvate:ferredoxin oxidoreductase gamma subunit PorG; arCOG01603; gene: porG.
     
 0.755
BTN85_1095
Isopropylmalate/homocitrate/citramalate synthase LeuA family; arCOG02093; gene: leuA; Belongs to the alpha-IPM synthase/homocitrate synthase family.
     
 0.755
BTN85_1473
NADH dehydrogenase subunit I; arCOG01543; gene: nuoI.
     
 0.754
BTN85_0068
Pyruvate:ferredoxin oxidoreductase beta subunit PorB; arCOG01601; gene: porB.
     
 0.734
Your Current Organism:
Methanohalarchaeum thermophilum
NCBI taxonomy Id: 1903181
Other names: C. Methanohalarchaeum thermophilum, Candidatus Methanohalarchaeum thermophilum, Euryarchaeota archaeon HMET1, archaeon HMET1, strain HMET1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.