STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BTN85_0457RPA family protein a subunit of RPA complex; arCOG02257. (251 aa)    
Predicted Functional Partners:
BTN85_0456
Single-stranded DNA-binding replication protein A (RPA), large subunit; arCOG01510; gene: RPA1.
   
 0.933
BTN85_0151
Signal peptidase I LepB; arCOG01739; gene: lepB.
  
     0.697
BTN85_0569
Presenilin-like membrane protease A22 family; arCOG04463.
  
     0.687
priL
Eukaryotic-type DNA primase large subunit PRI2; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
     0.685
priS
Eukaryotic-type DNA primase catalytic small subunit PRI1; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer ext [...]
  
     0.665
BTN85_1414
OxaA/SpoJ/YidC translocase/secretase; arCOG02673.
  
     0.661
BTN85_0653
Queuine tRNA-ribosyltransferase containing PUA domain; arCOG00990.
  
     0.660
BTN85_0444
Putative archaeal coiled-coil protein; arCOG01159.
  
     0.654
BTN85_1688
Putative cell division protein SepF-like; arCOG02263.
  
     0.629
pcn
DNA polymerase sliding clamp subunit PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
     0.628
Your Current Organism:
Methanohalarchaeum thermophilum
NCBI taxonomy Id: 1903181
Other names: C. Methanohalarchaeum thermophilum, Candidatus Methanohalarchaeum thermophilum, Euryarchaeota archaeon HMET1, archaeon HMET1, strain HMET1
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