BTN85_1696 protein (Methanohalarchaeum thermophilum)

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Predicted Interactions

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BTN85_1696

Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20. (167 aa)

Predicted Functional Partners:

rps3ae

0.807

rps4e

0.736

rps17

0.734

rps6e

0.714

rps19e

0.690

rps28e

0.688

rps3

0.683

rps2

0.676

rps19p

0.646

rps17e

0.644

Your Current Organism:

Methanohalarchaeum thermophilum

NCBI taxonomy Id: 1903181
Other names: C. Methanohalarchaeum thermophilum, Candidatus Methanohalarchaeum thermophilum, Euryarchaeota archaeon HMET1, archaeon HMET1, strain HMET1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTN85_1696	rps17	BTN85_1696	BTN85_1399	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	0.734
BTN85_1696	rps17e	BTN85_1696	BTN85_0066	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S17E; arCOG01885; gene: RPS17A; Belongs to the eukaryotic ribosomal protein eS17 family.	0.644
BTN85_1696	rps19e	BTN85_1696	BTN85_1707	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family.	0.690
BTN85_1696	rps19p	BTN85_1696	BTN85_1394	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.646
BTN85_1696	rps2	BTN85_1696	BTN85_1778	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S2; arCOG04245; gene: rpsB; Belongs to the universal ribosomal protein uS2 family.	0.676
BTN85_1696	rps28e	BTN85_1696	BTN85_1770	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S28E/S33; arCOG04314; gene: RPS28A; Belongs to the eukaryotic ribosomal protein eS28 family.	0.688
BTN85_1696	rps3	BTN85_1696	BTN85_1396	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.	0.683
BTN85_1696	rps3ae	BTN85_1696	BTN85_0722	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S3AE; arCOG04186; gene: RPS1A; Belongs to the eukaryotic ribosomal protein eS1 family.	0.807
BTN85_1696	rps4e	BTN85_1696	BTN85_1402	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S4E; arCOG04093; gene: RPS4A; Belongs to the eukaryotic ribosomal protein eS4 family.	0.736
BTN85_1696	rps6e	BTN85_1696	BTN85_1761	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	Ribosomal protein S6E/S10; arCOG01946; gene: RPS6A; Belongs to the eukaryotic ribosomal protein eS6 family.	0.714
rps17	BTN85_1696	BTN85_1399	BTN85_1696	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Putative RNA-binding protein containing PUA domain Tma20; arCOG00985; gene: tma20.	0.734
rps17	rps17e	BTN85_1399	BTN85_0066	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S17E; arCOG01885; gene: RPS17A; Belongs to the eukaryotic ribosomal protein eS17 family.	0.999
rps17	rps19e	BTN85_1399	BTN85_1707	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family.	0.999
rps17	rps19p	BTN85_1399	BTN85_1394	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.999
rps17	rps2	BTN85_1399	BTN85_1778	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S2; arCOG04245; gene: rpsB; Belongs to the universal ribosomal protein uS2 family.	0.999
rps17	rps28e	BTN85_1399	BTN85_1770	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S28E/S33; arCOG04314; gene: RPS28A; Belongs to the eukaryotic ribosomal protein eS28 family.	0.999
rps17	rps3	BTN85_1399	BTN85_1396	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.	0.999
rps17	rps3ae	BTN85_1399	BTN85_0722	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S3AE; arCOG04186; gene: RPS1A; Belongs to the eukaryotic ribosomal protein eS1 family.	0.999
rps17	rps4e	BTN85_1399	BTN85_1402	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S4E; arCOG04093; gene: RPS4A; Belongs to the eukaryotic ribosomal protein eS4 family.	0.999
rps17	rps6e	BTN85_1399	BTN85_1761	Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.	Ribosomal protein S6E/S10; arCOG01946; gene: RPS6A; Belongs to the eukaryotic ribosomal protein eS6 family.	0.999

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Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.922

expected number of edges:

10

PPI enrichment p-value:

1.04e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006644

Phospholipid metabolic process

6 of 125

1.74

2.42

1.48e-06

GO:0008654

Phospholipid biosynthetic process

5 of 95

1.78

2.21

8.94e-06

GO:0006650

Glycerophospholipid metabolic process

5 of 97

1.77

2.2

8.94e-06

GO:0006629

Lipid metabolic process

7 of 291

1.44

1.91

1.74e-06

GO:0046474

Glycerophospholipid biosynthetic process

4 of 76

1.78

1.79

0.00013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016780

Phosphotransferase activity, for other substituted phosphate groups

2 of 11

2.32

0.9

0.0223

GO:0042578

Phosphoric ester hydrolase activity

4 of 174

1.42

0.89

0.0103

GO:0003824

Catalytic activity

10 of 3163

0.56

0.4

0.0103

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15229

Inositol phosphate metabolism

3 of 12

2.46

1.84

0.00038

CL:9328

Mixed, incl. Glycerophospholipid catabolic process, and Cell cycle G1/S phase transition

3 of 13

2.42

1.83

0.00038

CL:13210

Phospholipid metabolism, and Phosphatidylserine decarboxylase

2 of 6

2.58

1.31

0.0041

CL:9330

Mixed, incl. Cell cycle G1/S phase transition, and SPX domain

2 of 7

2.52

1.27

0.0047

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

5 of 76

1.88

2.74

5.88e-07

map00562

Inositol phosphate metabolism

3 of 43

1.9

1.62

0.00050

map00030

Pentose phosphate pathway

2 of 21

2.04

1.16

0.0060

map04070

Phosphatidylinositol signaling system

2 of 48

1.68

0.82

0.0228

map01100

Metabolic pathways

8 of 1691

0.74

0.61

0.00054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1855183

Synthesis of IP2, IP, and Ins in the cytosol

2 of 5

2.66

1.12

0.0093

MAP-71336

Pentose phosphate pathway

2 of 14

2.22

0.87

0.0242

MAP-1483249

Inositol phosphate metabolism

2 of 16

2.16

0.87

0.0242

MAP-71387

Metabolism of carbohydrates

3 of 137

1.4

0.68

0.0362

MAP-1430728

Metabolism

7 of 1121

0.86

0.59

0.0093

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0460

Magnesium

3 of 46

1.88

1.36

0.0019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00459

Inositol monophosphatase family

2 of 2

3.06

1.34

0.0038

PF01066

CDP-alcohol phosphatidyltransferase

2 of 5

2.66

1.2

0.0066

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020583

Inositol monophosphatase, metal-binding site

2 of 2

3.06

1.08

0.0112

IPR020550

Inositol monophosphatase, conserved site

2 of 2

3.06

1.08

0.0112

IPR000760

Inositol monophosphatase-like

2 of 2

3.06

1.08

0.0112

IPR043130

CDP-alcohol phosphatidyltransferase, transmembrane domain

2 of 5

2.66

1.07

0.0112

IPR000462

CDP-alcohol phosphatidyltransferase

2 of 5

2.66

1.07

0.0112

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