STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BTN85_17503-phosphoglycerate kinase Pgk; arCOG00496; gene: pgk. (412 aa)    
Predicted Functional Partners:
eno
Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 0.982
gap
Glyceraldehyde-3-phosphate dehydrogenase GapA; arCOG00493; gene: gapA.
 
 0.981
tpiA
Triosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 0.956
BTN85_0438
Glucose-6-phosphate isomerase Pgi; arCOG00052; gene: pgi.
  
 0.933
BTN85_1391
Ribosomal protein L4; arCOG04071; gene: rplD.
  
 0.862
BTN85_0140
Aspartate-semialdehyde dehydrogenase Acd; arCOG00494; gene: asd.
  
 0.831
pan
ATP-dependent 26S proteasome regulatory subunit; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone pro [...]
   
 0.679
apgM
23-bisphosphoglycerate-independent phosphoglycerate mutase ApgM; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
 0.664
rbcL
Ribulose 15-bisphosphate carboxylase large subunit RbcL; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily.
    
 0.661
BTN85_1560
Lactaldehyde dehydrogenase CofA; arCOG01252; gene: cofA; Belongs to the aldehyde dehydrogenase family.
   
 0.655
Your Current Organism:
Methanohalarchaeum thermophilum
NCBI taxonomy Id: 1903181
Other names: C. Methanohalarchaeum thermophilum, Candidatus Methanohalarchaeum thermophilum, Euryarchaeota archaeon HMET1, archaeon HMET1, strain HMET1
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