BTN85_2166 protein (Methanohalarchaeum thermophilum)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

BTN85_2166

Mannose-1-phosphate guanylyltransferase fused to cupin domain; arCOG02427; gene: manC; Belongs to the mannose-6-phosphate isomerase type 2 family. (444 aa)

Predicted Functional Partners:

BTN85_0438

0.982

BTN85_2059

0.970

BTN85_0378

0.963

BTN85_0390

0.811

BTN85_0671

0.779

BTN85_0033

0.761

BTN85_2060

0.620

BTN85_2061

0.620

BTN85_1076

0.590

BTN85_2056

0.574

Your Current Organism:

Methanohalarchaeum thermophilum

NCBI taxonomy Id: 1903181
Other names: C. Methanohalarchaeum thermophilum, Candidatus Methanohalarchaeum thermophilum, Euryarchaeota archaeon HMET1, archaeon HMET1, strain HMET1

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
BTN85_0033	BTN85_0378	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	0.796
BTN85_0033	BTN85_0390	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	0.658
BTN85_0033	BTN85_0438	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	Glucose-6-phosphate isomerase Pgi; arCOG00052; gene: pgi.	0.900
BTN85_0033	BTN85_0671	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	Glycosyl transferase family 2; arCOG01389.	0.760
BTN85_0033	BTN85_2056	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	Glucose-1-phosphate uridyltransferase AglF; arCOG00664; gene: aglF.	0.664
BTN85_0033	BTN85_2060	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	0.694
BTN85_0033	BTN85_2061	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	0.598
BTN85_0033	BTN85_2166	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	Mannose-1-phosphate guanylyltransferase fused to cupin domain; arCOG02427; gene: manC; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.761
BTN85_0378	BTN85_0033	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	0.796
BTN85_0378	BTN85_0390	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	0.958
BTN85_0378	BTN85_0438	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	Glucose-6-phosphate isomerase Pgi; arCOG00052; gene: pgi.	0.989
BTN85_0378	BTN85_0671	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	Glycosyl transferase family 2; arCOG01389.	0.608
BTN85_0378	BTN85_1076	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	NUDIX family hydrolase; arCOG01075.	0.772
BTN85_0378	BTN85_2056	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	Glucose-1-phosphate uridyltransferase AglF; arCOG00664; gene: aglF.	0.989
BTN85_0378	BTN85_2059	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	UDP-glucose 6-dehydrogenase, aglM/ugd; arCOG00253; gene: aglM/ugd.	0.987
BTN85_0378	BTN85_2060	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	0.745
BTN85_0378	BTN85_2061	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	0.901
BTN85_0378	BTN85_2166	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	Mannose-1-phosphate guanylyltransferase fused to cupin domain; arCOG02427; gene: manC; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.963
BTN85_0390	BTN85_0033	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate.	0.658
BTN85_0390	BTN85_0378	N-acetylglucosamine-1-phosphate uridyltransferase; arCOG00666; gene: GCD1.	Phosphomannomutase; arCOG00767; gene: manB; Belongs to the phosphohexose mutase family.	0.958

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.876

expected number of edges:

11

PPI enrichment p-value:

1.44e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046395

Carboxylic acid catabolic process

6 of 155

1.71

2.25

3.69e-06

GO:0044282

Small molecule catabolic process

7 of 235

1.6

2.24

1.00e-06

GO:0009063

Cellular amino acid catabolic process

4 of 77

1.84

1.69

0.00029

GO:0006520

Cellular amino acid metabolic process

5 of 205

1.51

1.45

0.00029

GO:0019752

Carboxylic acid metabolic process

7 of 555

1.22

1.28

7.10e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016405

CoA-ligase activity

3 of 15

2.42

1.69

0.00070

GO:0016878

Acid-thiol ligase activity

3 of 22

2.26

1.59

0.00098

GO:0050218

propionate-CoA ligase activity

2 of 2

3.12

1.54

0.0017

GO:0003987

acetate-CoA ligase activity

2 of 2

3.12

1.54

0.0017

GO:0016491

Oxidoreductase activity

6 of 600

1.12

0.92

0.0017

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

10 of 1137

1.07

1.31

1.27e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18031

Valine, leucine and isoleucine degradation, and Peroxisomal lipid metabolism

8 of 80

2.12

5.23

6.40e-13

CL:18143

Aldehyde dehydrogenase family, and Branched-chain amino acid catabolism

5 of 15

2.65

4.71

1.01e-09

CL:18145

Degradation of GABA, and Phytol metabolic process

3 of 5

2.9

2.75

9.32e-06

CL:18032

Fatty acid beta-oxidation, and Biotin transport and metabolism

3 of 55

1.86

1.19

0.0043

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00280

Valine, leucine and isoleucine degradation

7 of 53

2.24

5.4

1.55e-12

map00640

Propanoate metabolism

4 of 35

2.18

2.87

1.63e-06

map00410

beta-Alanine metabolism

3 of 31

2.11

1.93

0.00016

map00380

Tryptophan metabolism

3 of 44

1.96

1.73

0.00033

map00250

Alanine, aspartate and glutamate metabolism

3 of 43

1.97

1.73

0.00033

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71384

Ethanol oxidation

2 of 5

2.73

1.13

0.0089

MAP-1430728

Metabolism

10 of 1828

0.86

0.85

1.56e-05

MAP-71291

Metabolism of amino acids and derivatives

4 of 252

1.32

0.79

0.0152

MAP-211945

Phase I - Functionalization of compounds

3 of 105

1.58

0.78

0.0257

MAP-70895

Branched-chain amino acid catabolism

2 of 20

2.12

0.76

0.0390

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000759

Liver

5 of 504

1.12

0.6

0.0336

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

9 of 637

1.27

1.79

5.05e-08

GOCC:0005737

Cytoplasm

10 of 4348

0.48

0.32

0.0360

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

4 of 157

1.53

1.25

0.0014

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13193

AMP-binding enzyme C-terminal domain

3 of 10

2.6

2.05

0.00016

PF00501

AMP-binding enzyme

3 of 21

2.28

1.72

0.00056

PF16177

Acetyl-coenzyme A synthetase N-terminus

2 of 2

3.12

1.52

0.0018

PF00202

Aminotransferase class-III

2 of 5

2.73

1.28

0.0048

PF00171

Aldehyde dehydrogenase family

2 of 16

2.22

0.84

0.0276

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025110

AMP-binding enzyme, C-terminal domain

3 of 11

2.56

1.78

0.00053

IPR045851

AMP-binding enzyme, C-terminal domain superfamily

3 of 12

2.52

1.77

0.00053

IPR042099

ANL, N-terminal domain

3 of 13

2.49

1.77

0.00053

IPR020845

AMP-binding, conserved site

3 of 12

2.52

1.77

0.00053

IPR000873

AMP-dependent synthetase/ligase domain

3 of 13

2.49

1.77

0.00053

(more ...)

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