| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XCC3903 | appA | XCC3903 | XCC0760 | Hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphoanhydride phosphohydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.900 |
| XCC3903 | phoC | XCC3903 | XCC4236 | Hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphatase precursor; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.902 |
| XCC3903 | ribD | XCC3903 | XCC0693 | Hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin-specific deaminase/5-amino-6-uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.925 |
| XCC3903 | ribE | XCC3903 | XCC0695 | Hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin synthase alpha chain; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.901 |
| XCC3903 | ribF | XCC3903 | XCC1154 | Hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin biosynthesis protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ribF family. | 0.918 |
| XCC3903 | ribH | XCC3903 | XCC0697 | Hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.903 |
| appA | XCC3903 | XCC0760 | XCC3903 | Phosphoanhydride phosphohydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.900 |
| appA | phoC | XCC0760 | XCC4236 | Phosphoanhydride phosphohydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphatase precursor; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.933 |
| appA | ribE | XCC0760 | XCC0695 | Phosphoanhydride phosphohydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin synthase alpha chain; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.900 |
| appA | ribF | XCC0760 | XCC1154 | Phosphoanhydride phosphohydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin biosynthesis protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ribF family. | 0.900 |
| nrdR | nusB | XCC0691 | XCC0698 | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.631 |
| nrdR | ribA | XCC0691 | XCC0696 | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.689 |
| nrdR | ribD | XCC0691 | XCC0693 | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Riboflavin-specific deaminase/5-amino-6-uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.989 |
| nrdR | ribE | XCC0691 | XCC0695 | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Riboflavin synthase alpha chain; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.869 |
| nrdR | ribF | XCC0691 | XCC1154 | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | Riboflavin biosynthesis protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the ribF family. | 0.856 |
| nrdR | ribH | XCC0691 | XCC0697 | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. | 0.429 |
| nusB | nrdR | XCC0698 | XCC0691 | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.631 |
| nusB | ribA | XCC0698 | XCC0696 | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.862 |
| nusB | ribD | XCC0698 | XCC0693 | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | Riboflavin-specific deaminase/5-amino-6-uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.785 |
| nusB | ribE | XCC0698 | XCC0695 | Transcription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | Riboflavin synthase alpha chain; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.666 |