| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cicA | hisA | XCC1338 | XCC1813 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.635 |
| cicA | hisB | XCC1338 | XCC1811 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Imidazoleglycerolphosphate dehydratase/histidinol-phosphate phosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.797 |
| cicA | hisD | XCC1338 | XCC1809 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.611 |
| cicA | hisF | XCC1338 | XCC1814 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.692 |
| cicA | hisH | XCC1338 | XCC1812 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.668 |
| cicA | hisI | XCC1338 | XCC1815 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the C-terminal section; belongs to the PRA-PH family. | 0.952 |
| cicA | metS | XCC1338 | XCC1339 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.521 |
| cicA | pheA-2 | XCC1338 | XCC1590 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | P-protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.477 |
| cicA | serC | XCC1338 | XCC1589 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.444 |
| cicA | ydgM | XCC1338 | XCC1337 | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Ferredoxin II; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. | 0.774 |
| hisA | cicA | XCC1813 | XCC1338 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.635 |
| hisA | hisB | XCC1813 | XCC1811 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Imidazoleglycerolphosphate dehydratase/histidinol-phosphate phosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.999 |
| hisA | hisD | XCC1813 | XCC1809 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
| hisA | hisF | XCC1813 | XCC1814 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisA | hisH | XCC1813 | XCC1812 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | hisI | XCC1813 | XCC1815 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
| hisA | metS | XCC1813 | XCC1339 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.405 |
| hisA | pheA-2 | XCC1813 | XCC1590 | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | P-protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.586 |
| hisB | cicA | XCC1811 | XCC1338 | Imidazoleglycerolphosphate dehydratase/histidinol-phosphate phosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the histidinol- phosphatase family. | Phosphotransferase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.797 |
| hisB | hisA | XCC1811 | XCC1813 | Imidazoleglycerolphosphate dehydratase/histidinol-phosphate phosphatase bifunctional enzyme; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; In the N-terminal section; belongs to the histidinol- phosphatase family. | Phosphoribosylformimino-5-aminoimidazole carboxam; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.999 |