| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MazG | XCC3446 | XCC2881 | XCC3446 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Bifunctional NMN adenylyltransferase/nudix hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.918 |
| MazG | guaA | XCC2881 | XCC2183 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.902 |
| MazG | nadD | XCC2881 | XCC2616 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.901 |
| MazG | nadE | XCC2881 | XCC3091 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.900 |
| MazG | nadK | XCC2881 | XCC1546 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.900 |
| MazG | nudC | XCC2881 | XCC0489 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | NADH pyrophosphatase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.909 |
| XCC3092 | nadE | XCC3092 | XCC3091 | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.785 |
| XCC3446 | MazG | XCC3446 | XCC2881 | Bifunctional NMN adenylyltransferase/nudix hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.918 |
| XCC3446 | nadD | XCC3446 | XCC2616 | Bifunctional NMN adenylyltransferase/nudix hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.936 |
| XCC3446 | nadE | XCC3446 | XCC3091 | Bifunctional NMN adenylyltransferase/nudix hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.969 |
| XCC3446 | nadK | XCC3446 | XCC1546 | Bifunctional NMN adenylyltransferase/nudix hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.931 |
| XCC3446 | nudC | XCC3446 | XCC0489 | Bifunctional NMN adenylyltransferase/nudix hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | NADH pyrophosphatase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.907 |
| XCC3446 | purL | XCC3446 | XCC0656 | Bifunctional NMN adenylyltransferase/nudix hydrolase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Phosphoribosylformylglycinamidine synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.422 |
| birA | guaA | XCC3938 | XCC2183 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | 0.691 |
| birA | nadD | XCC3938 | XCC2616 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.635 |
| birA | nadE | XCC3938 | XCC3091 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.704 |
| birA | ribD | XCC3938 | XCC0693 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Riboflavin-specific deaminase/5-amino-6-uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.686 |
| guaA | MazG | XCC2183 | XCC2881 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.902 |
| guaA | birA | XCC2183 | XCC3938 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.691 |
| guaA | nadE | XCC2183 | XCC3091 | Glutamine amidotransferase; Catalyzes the synthesis of GMP from XMP. | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.704 |