| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| XCC1767 | birA | XCC1767 | XCC3938 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.532 |
| XCC1767 | folB | XCC1767 | XCC3815 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.991 |
| XCC1767 | folC | XCC1767 | XCC0950 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Folylpolyglutamate synthase/dihydrofolate synthase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark; Belongs to the folylpolyglutamate synthase family. | 0.733 |
| XCC1767 | folE | XCC1767 | XCC4166 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | GTP cyclohydrolase I; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.985 |
| XCC1767 | folK | XCC1767 | XCC3433 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.921 |
| XCC1767 | folP | XCC1767 | XCC1714 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| XCC1767 | ribD | XCC1767 | XCC0693 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Riboflavin-specific deaminase/5-amino-6-uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.702 |
| XCC3434 | XCC3435 | XCC3434 | XCC3435 | Histidine kinase/response regulator hybrid protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Two-component system regulatory protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.935 |
| XCC3434 | XCC3436 | XCC3434 | XCC3436 | Histidine kinase/response regulator hybrid protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Two-component system sensor protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.982 |
| XCC3434 | folK | XCC3434 | XCC3433 | Histidine kinase/response regulator hybrid protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.545 |
| XCC3435 | XCC3434 | XCC3435 | XCC3434 | Two-component system regulatory protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Histidine kinase/response regulator hybrid protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.935 |
| XCC3435 | XCC3436 | XCC3435 | XCC3436 | Two-component system regulatory protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Two-component system sensor protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.958 |
| XCC3435 | folK | XCC3435 | XCC3433 | Two-component system regulatory protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.532 |
| XCC3436 | XCC3434 | XCC3436 | XCC3434 | Two-component system sensor protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Histidine kinase/response regulator hybrid protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.982 |
| XCC3436 | XCC3435 | XCC3436 | XCC3435 | Two-component system sensor protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | Two-component system regulatory protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.958 |
| XCC3436 | folK | XCC3436 | XCC3433 | Two-component system sensor protein; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.532 |
| birA | XCC1767 | XCC3938 | XCC1767 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.532 |
| birA | folB | XCC3938 | XCC3815 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.702 |
| birA | folE | XCC3938 | XCC4166 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GTP cyclohydrolase I; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.552 |
| birA | folK | XCC3938 | XCC3433 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; Identified by sequence similarity; putative; ORF located using Blastx/Glimmer/Genemark. | 0.532 |