node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
W5S_2296 | W5S_3639 | W5S_2296 | W5S_3639 | Histidinol-phosphate aminotransferase 1. | D,D-heptose 1,7-bisphosphate phosphatase. | 0.682 |
W5S_2296 | hisA | W5S_2296 | W5S_1953 | Histidinol-phosphate aminotransferase 1. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.859 |
W5S_2296 | hisB | W5S_2296 | W5S_1955 | Histidinol-phosphate aminotransferase 1. | Histidine biosynthesis bifunctional protein HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.996 |
W5S_2296 | hisC | W5S_2296 | W5S_1956 | Histidinol-phosphate aminotransferase 1. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.749 |
W5S_2296 | hisD | W5S_2296 | W5S_1957 | Histidinol-phosphate aminotransferase 1. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.955 |
W5S_2296 | hisF | W5S_2296 | W5S_1952 | Histidinol-phosphate aminotransferase 1. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.933 |
W5S_2296 | hisG | W5S_2296 | W5S_1958 | Histidinol-phosphate aminotransferase 1. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.857 |
W5S_2296 | hisH | W5S_2296 | W5S_1954 | Histidinol-phosphate aminotransferase 1. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.936 |
W5S_2296 | hisI | W5S_2296 | W5S_1951 | Histidinol-phosphate aminotransferase 1. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.972 |
W5S_3639 | W5S_2296 | W5S_3639 | W5S_2296 | D,D-heptose 1,7-bisphosphate phosphatase. | Histidinol-phosphate aminotransferase 1. | 0.682 |
W5S_3639 | hisA | W5S_3639 | W5S_1953 | D,D-heptose 1,7-bisphosphate phosphatase. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.613 |
W5S_3639 | hisC | W5S_3639 | W5S_1956 | D,D-heptose 1,7-bisphosphate phosphatase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.682 |
W5S_3639 | hisD | W5S_3639 | W5S_1957 | D,D-heptose 1,7-bisphosphate phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.789 |
W5S_3639 | hisF | W5S_3639 | W5S_1952 | D,D-heptose 1,7-bisphosphate phosphatase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.790 |
W5S_3639 | hisG | W5S_3639 | W5S_1958 | D,D-heptose 1,7-bisphosphate phosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.581 |
W5S_3639 | hisH | W5S_3639 | W5S_1954 | D,D-heptose 1,7-bisphosphate phosphatase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.815 |
W5S_3639 | hisI | W5S_3639 | W5S_1951 | D,D-heptose 1,7-bisphosphate phosphatase. | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. | 0.901 |
hisA | W5S_2296 | W5S_1953 | W5S_2296 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase 1. | 0.859 |
hisA | W5S_3639 | W5S_1953 | W5S_3639 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | D,D-heptose 1,7-bisphosphate phosphatase. | 0.613 |
hisA | hisB | W5S_1953 | W5S_1955 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidine biosynthesis bifunctional protein HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.998 |