STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KDS85070.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (81 aa)    
Predicted Functional Partners:
KDS85071.1
Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
tylE
Hypothetical protein; O-methyltransferase that catalyzes the conversion of demethylmacrocin to macrocin, the penultimate step of tylosin antibiotic biosynthesis. Also able to mediate the conversion of demethyllactenocin to lactenocin.
       0.723
KDS85635.1
2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.718
tylH1
Hypothetical protein; Involved in the biosynthesis of the complex macrolide antibiotic tylosin. Catalyzes the hydroxylation of 20-oxo-5-O-beta- mycaminosyltylactone at the C-23 position to yield 5-O-beta- mycaminosyltylonolide; Belongs to the cytochrome P450 family.
 
  
 0.705
KDS89970.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.627
KDS89031.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.623
KDS89893.1
Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.541
tylN
Hypothetical protein; Involved in the biosynthesis of the macrolide antibiotic tylosin derived from the polyketide lactone tylactone. Catalyzes the transfer of 6-deoxy-alpha-D-allose from dTDP-6-deoxy-alpha-D-allose to O-mycaminosyltylonolide (OMT) to yield demethyllactenocin.
       0.541
KDS89722.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.499
KDS84422.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.458
Your Current Organism:
Streptomyces fradiae
NCBI taxonomy Id: 1906
Other names: ATCC 10745, ATCC 19760, Actinomyces fradii, BCRC 12196, CBS 498.68, CCM 3174, CCRC 12196, CCRC:12196, CECT 3197, DSM 40063, HAMBI 965, HUT 6095, IFO 12773, IFO 3718, IMET 42051, IMI 061202, ISP 5063, JCM 4133, JCM 4579, JCM 4824 [[Streptomyces roseoflavus]], KCTC 9760, NBRC 12773, NBRC 13439 [[Streptomyces roseoflavus]], NBRC 3718, NCIMB 11005, NCIMB 8233, NRRL B-2789 [[Streptomyces roseoflavus]], NRRL-ISP 5063, PCM 2330, RIA 97, S. fradiae, Streptomyces fradiae subsp. fradiae, Streptomyces fradii, Streptomyces roseiflavus, Streptomyces roseoflavus, Streptomyces sp. NEAE-82, UNIQEM 146, VKM Ac-150, VKM Ac-151, VKM Ac-152, VKM Ac-764
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