STRINGSTRING
glnD protein (Caulobacter crescentus CB15) - STRING interaction network
"glnD" - Bifunctional uridylyltransferase/uridylyl-removing enzyme in Caulobacter crescentus CB15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnDBifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and met [...] (940 aa)    
Predicted Functional Partners:
CC_1968
Nitrogen regulatory protein P-II 1; Identified by match to protein family HMM; Belongs to the P(II) protein family (112 aa)
 
  0.964
glnE
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] (986 aa)
   
   
  0.942
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (903 aa)
   
        0.874
CC_1339
Nitrogen regulatory protein P-II 2; Identified by match to protein family HMM; Belongs to the P(II) protein family (112 aa)
 
 
  0.814
CC_1740
Nitrogen regulation protein NR(II); Identified by match to protein family HMM (363 aa)
   
 
 
  0.677
CC_0521
Identified by match to protein family HMM; Belongs to the P(II) protein family (114 aa)
 
 
  0.666
CC_3607
Glutamate synthase, large subunit; Identified by match to PFAM protein family HMM PF01645 (1508 aa)
         
  0.647
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (385 aa)
         
  0.610
CC_1471
Pyruvate, phosphate dikinase; Identified by match to protein family HMM; Belongs to the PEP-utilizing enzyme family (900 aa)
     
   
  0.605
CC_1338
Ammonium transporter; Identified by match to TIGR protein family HMM TIGR00836 (510 aa)
   
   
  0.600
Your Current Organism:
Caulobacter crescentus CB15
NCBI taxonomy Id: 190650
Other names: C. crescentus CB15, Caulobacter crescentus CB15, Caulobacter crescentus str. CB15, Caulobacter crescentus strain CB15, Caulobacter vibrioides ATCC 19089, Caulobacter vibrioides CB15
Server load: low (14%) [HD]