node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CC_0261 | CC_0532 | CC_0261 | CC_0532 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Mandelate racemase/muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | 0.426 |
CC_0261 | CC_2812 | CC_0261 | CC_2812 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Mandelate racemase / muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | 0.436 |
CC_0261 | NrdF | CC_0261 | CC_0260 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.453 |
CC_0261 | alkB | CC_0261 | CC_0009 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | DNA alkylation damage repair protein AlkB; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents) (By s [...] | 0.655 |
CC_0261 | ilvC | CC_0261 | CC_2120 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.826 |
CC_0261 | nadE | CC_0261 | CC_3619 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | NAD(+) synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.416 |
CC_0261 | panB | CC_0261 | CC_1651 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.983 |
CC_0261 | panC | CC_0261 | CC_2166 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.981 |
CC_0261 | ribB | CC_0261 | CC_0887 | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.467 |
CC_0532 | CC_0261 | CC_0532 | CC_0261 | Mandelate racemase/muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.426 |
CC_0532 | CC_2812 | CC_0532 | CC_2812 | Mandelate racemase/muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | Mandelate racemase / muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | 0.901 |
CC_2812 | CC_0261 | CC_2812 | CC_0261 | Mandelate racemase / muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.436 |
CC_2812 | CC_0532 | CC_2812 | CC_0532 | Mandelate racemase / muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | Mandelate racemase/muconate lactonizing enzyme family; Catalyzes the dehydration of D-mannonate. Has no detectable activity with a panel of 70 other acid sugars (in vitro). | 0.901 |
NrdF | CC_0261 | CC_0260 | CC_0261 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.453 |
alkB | CC_0261 | CC_0009 | CC_0261 | DNA alkylation damage repair protein AlkB; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha- ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents) (By s [...] | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.655 |
ilvC | CC_0261 | CC_2120 | CC_0261 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.826 |
ilvC | panB | CC_2120 | CC_1651 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.586 |
ilvC | panC | CC_2120 | CC_2166 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.662 |
nadE | CC_0261 | CC_3619 | CC_0261 | NAD(+) synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.416 |
nadE | panC | CC_3619 | CC_2166 | NAD(+) synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.474 |