Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
parE1Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD1 but no other ParD or RelB antitoxin. Low levels of wild-type toxin in the absence of antitoxin decreases the rate of cell growth, and results in death or loss of colony formation abilities and greatly elongated cells. Low levels of a mutant missing the last 4 residues leads to loss of cell division while cell elongation continues. (96 aa)    
Predicted Functional Partners:
parD1
Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin ParE1, but no other RelE or ParE toxin. May act as a DNA gyrase inhibitor (By similarity).
 
 
 0.999
parE4
Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD4 but no other ParD or RelB antitoxin.
  
   
 0.946
parD4
Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin ParE4, but no other RelE or ParE toxin.
 
 
 0.904
parD2
Hypothetical protein; Antitoxin component of a non-functional type II toxin- antitoxin (TA system). Does not neutralize the effect of any of the RelE or ParE toxins.
  
 
 0.900
parE
Topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.787
parE3
Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Its toxic effect is neutralized by coexpression with cognate antitoxin ParD3 but no other ParD or RelB antitoxin.
      
 0.787
prmC
hemK family protein; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
       0.572
relB2
Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin RelE2, but no other RelE or ParE toxin.
  
   0.550
CC_0731
Hypothetical protein; Identified by Glimmer2; putative.
      
 0.472
CC_1382
Aminotransferase, class I; Identified by match to protein family HMM.
      
 0.472
Your Current Organism:
Caulobacter vibrioides CB15
NCBI taxonomy Id: 190650
Other names: C. vibrioides CB15, Caulobacter crescentus CB15, Caulobacter vibrioides ATCC 19089
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