| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CC_0027 | FixK | CC_0027 | CC_0752 | Conserved hypothetical protein; Identified by Glimmer2; putative. | Transcriptional regulator, Crp family; Identified by match to protein family HMM. | 0.741 |
| CC_0027 | ahpD | CC_0027 | CC_3698 | Conserved hypothetical protein; Identified by Glimmer2; putative. | Alkyl hydroperoxide reductase D; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.732 |
| CC_0027 | hup | CC_0027 | CC_1959 | Conserved hypothetical protein; Identified by Glimmer2; putative. | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | 0.517 |
| CC_3176 | hup | CC_3176 | CC_1959 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by match to PFAM protein family HMM PF01558. | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | 0.742 |
| FixK | CC_0027 | CC_0752 | CC_0027 | Transcriptional regulator, Crp family; Identified by match to protein family HMM. | Conserved hypothetical protein; Identified by Glimmer2; putative. | 0.741 |
| FixK | hup | CC_0752 | CC_1959 | Transcriptional regulator, Crp family; Identified by match to protein family HMM. | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | 0.574 |
| ahpD | CC_0027 | CC_3698 | CC_0027 | Alkyl hydroperoxide reductase D; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Conserved hypothetical protein; Identified by Glimmer2; putative. | 0.732 |
| ahpD | hup | CC_3698 | CC_1959 | Alkyl hydroperoxide reductase D; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | 0.527 |
| clpX | hup | CC_1961 | CC_1959 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | 0.484 |
| clpX | lon | CC_1961 | CC_1960 | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent protease LA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). CcrM is an important target of the Lon protease pathway in C.crescentus (By similarity). | 0.931 |
| hup | CC_0027 | CC_1959 | CC_0027 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | Conserved hypothetical protein; Identified by Glimmer2; putative. | 0.517 |
| hup | CC_3176 | CC_1959 | CC_3176 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by match to PFAM protein family HMM PF01558. | 0.742 |
| hup | FixK | CC_1959 | CC_0752 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | Transcriptional regulator, Crp family; Identified by match to protein family HMM. | 0.574 |
| hup | ahpD | CC_1959 | CC_3698 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | Alkyl hydroperoxide reductase D; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.527 |
| hup | clpX | CC_1959 | CC_1961 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.484 |
| hup | ihfA | CC_1959 | CC_1370 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | Integration host factor alpha-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. | 0.646 |
| hup | katG | CC_1959 | CC_3043 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | Catalase/peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity). Important for stationary phase survival; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 0.469 |
| hup | lon | CC_1959 | CC_1960 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | ATP-dependent protease LA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). CcrM is an important target of the Lon protease pathway in C.crescentus (By similarity). | 0.556 |
| hup | polA | CC_1959 | CC_3464 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.521 |
| hup | rpsT | CC_1959 | CC_0007 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family. | Ribosomal protein S20; Binds directly to 16S ribosomal RNA. | 0.493 |