node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CC_0393 | CC_1383 | CC_0393 | CC_1383 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | 0.449 |
CC_0393 | CC_2100 | CC_0393 | CC_2100 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 0.916 |
CC_0393 | CC_3105 | CC_0393 | CC_3105 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Threonine dehydratase; Identified by match to protein family HMM. | 0.940 |
CC_0393 | CC_3635 | CC_0393 | CC_3635 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.954 |
CC_0393 | IlvH | CC_0393 | CC_2101 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.996 |
CC_0393 | ilvC | CC_0393 | CC_2120 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.969 |
CC_0393 | leuA | CC_0393 | CC_1541 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.928 |
CC_0393 | leuB | CC_0393 | CC_0193 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.950 |
CC_0393 | leuC | CC_0393 | CC_0196 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.507 |
CC_0393 | leuD | CC_0393 | CC_0195 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.541 |
CC_1383 | CC_0393 | CC_1383 | CC_0393 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 0.449 |
CC_1383 | CC_2100 | CC_1383 | CC_2100 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 0.523 |
CC_1383 | CC_3105 | CC_1383 | CC_3105 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | Threonine dehydratase; Identified by match to protein family HMM. | 0.470 |
CC_1383 | CC_3635 | CC_1383 | CC_3635 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.676 |
CC_1383 | IlvH | CC_1383 | CC_2101 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.897 |
CC_1383 | ilvC | CC_1383 | CC_2120 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.594 |
CC_1383 | leuB | CC_1383 | CC_0193 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.578 |
CC_1383 | leuC | CC_1383 | CC_0196 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.552 |
CC_1383 | leuD | CC_1383 | CC_0195 | Homoserine dehydrogenase; Identified by match to PFAM protein family HMM PF00742. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.434 |
CC_2100 | CC_0393 | CC_2100 | CC_0393 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 0.916 |