| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CC_2126 | CC_3355 | CC_2126 | CC_3355 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | 0.914 |
| CC_2126 | folD | CC_2126 | CC_1217 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.401 |
| CC_2126 | glyA | CC_2126 | CC_1357 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
| CC_2126 | thyA | CC_2126 | CC_2124 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| CC_2126 | tmk | CC_2126 | CC_1824 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.423 |
| CC_2140 | CC_3355 | CC_2140 | CC_3355 | 5,10-methylenetetrahydrofolate reductase; Identified by match to TIGR protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | 0.940 |
| CC_2140 | folD | CC_2140 | CC_1217 | 5,10-methylenetetrahydrofolate reductase; Identified by match to TIGR protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
| CC_2140 | gcvPB | CC_2140 | CC_3352 | 5,10-methylenetetrahydrofolate reductase; Identified by match to TIGR protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system P protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.921 |
| CC_2140 | glyA | CC_2140 | CC_1357 | 5,10-methylenetetrahydrofolate reductase; Identified by match to TIGR protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
| CC_2140 | thyA | CC_2140 | CC_2124 | 5,10-methylenetetrahydrofolate reductase; Identified by match to TIGR protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.917 |
| CC_3355 | CC_2126 | CC_3355 | CC_2126 | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.914 |
| CC_3355 | CC_2140 | CC_3355 | CC_2140 | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | 5,10-methylenetetrahydrofolate reductase; Identified by match to TIGR protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.940 |
| CC_3355 | folD | CC_3355 | CC_1217 | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
| CC_3355 | gcvPB | CC_3355 | CC_3352 | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | Glycine cleavage system P protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| CC_3355 | glyA | CC_3355 | CC_1357 | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
| CC_3355 | thyA | CC_3355 | CC_2124 | Glycine cleavage system T protein; Identified by match to TIGR protein family HMM TIGR00528. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.919 |
| MazG | surE | CC_1747 | CC_1998 | Mazg protein; Identified by match to protein family HMM. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.905 |
| MazG | thyA | CC_1747 | CC_2124 | Mazg protein; Identified by match to protein family HMM. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.936 |
| MazG | tmk | CC_1747 | CC_1824 | Mazg protein; Identified by match to protein family HMM. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.922 |
| dut | surE | CC_3713 | CC_1998 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
