node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CC_1897 | CC_2953 | CC_1897 | CC_2953 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | Para-aminobenzoate synthase, component I; Identified by match to PFAM protein family HMM PF00425. | 0.999 |
CC_1897 | aroA | CC_1897 | CC_3589 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.490 |
CC_1897 | aroB | CC_1897 | CC_3009 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.703 |
CC_1897 | aroC | CC_1897 | CC_3154 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.966 |
CC_1897 | aroE | CC_1897 | CC_0003 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.762 |
CC_1897 | aroK | CC_1897 | CC_3008 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.666 |
CC_1897 | trpE | CC_1897 | CC_1895 | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.999 |
CC_2224 | aroA | CC_2224 | CC_3589 | Cyclohexadienyl dehydrogenase; Identified by match to PFAM protein family HMM PF02153. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.987 |
CC_2224 | aroB | CC_2224 | CC_3009 | Cyclohexadienyl dehydrogenase; Identified by match to PFAM protein family HMM PF02153. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.766 |
CC_2224 | aroC | CC_2224 | CC_3154 | Cyclohexadienyl dehydrogenase; Identified by match to PFAM protein family HMM PF02153. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.843 |
CC_2224 | aroE | CC_2224 | CC_0003 | Cyclohexadienyl dehydrogenase; Identified by match to PFAM protein family HMM PF02153. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.417 |
CC_2224 | aroK | CC_2224 | CC_3008 | Cyclohexadienyl dehydrogenase; Identified by match to PFAM protein family HMM PF02153. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.603 |
CC_2224 | xerD | CC_2224 | CC_3006 | Cyclohexadienyl dehydrogenase; Identified by match to PFAM protein family HMM PF02153. | Integrase/recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. | 0.489 |
CC_2953 | CC_1897 | CC_2953 | CC_1897 | Para-aminobenzoate synthase, component I; Identified by match to PFAM protein family HMM PF00425. | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | 0.999 |
CC_2953 | aroB | CC_2953 | CC_3009 | Para-aminobenzoate synthase, component I; Identified by match to PFAM protein family HMM PF00425. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.591 |
CC_2953 | aroC | CC_2953 | CC_3154 | Para-aminobenzoate synthase, component I; Identified by match to PFAM protein family HMM PF00425. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.942 |
CC_2953 | aroE | CC_2953 | CC_0003 | Para-aminobenzoate synthase, component I; Identified by match to PFAM protein family HMM PF00425. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.661 |
CC_2953 | aroK | CC_2953 | CC_3008 | Para-aminobenzoate synthase, component I; Identified by match to PFAM protein family HMM PF00425. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.679 |
CC_2953 | trpE | CC_2953 | CC_1895 | Para-aminobenzoate synthase, component I; Identified by match to PFAM protein family HMM PF00425. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.850 |
aroA | CC_1897 | CC_3589 | CC_1897 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Glutamine amidotransferase, class I; Identified by match to protein family HMM. | 0.490 |