STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ctrACell cycle transcriptional regulator CtrA; Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA replication, DNA methylation, and class II flagellar biogenesis. (231 aa)    
Predicted Functional Partners:
CC_3470
Hypothetical protein; Identified by Glimmer2; putative.
  
 0.986
divJ
Sensor histidine kinase DivJ; Kinase required for the regulation of cell division and differentiation. Is part of a signal transduction pathway, activating PleD by phosphorylation.
 
 0.949
pleC
Non-motile and phage-resistance protein; Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator PleD, leading to its activation.
 
 0.934
divL
Tyrosine kinase DivL; Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter.
 
 
 0.922
rcdA
Hypothetical protein; Identified by Glimmer2; putative.
    
 
 0.872
clpX
ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.867
CC_2670
Sensory box histidine kinase/response regulator; Identified by match to protein family HMM.
 
0.859
CC_2971
Sensory box histidine kinase/response regulator; Identified by match to protein family HMM.
 
0.859
CC_0652
Sensory box histidine kinase/response regulator; Identified by match to protein family HMM.
 
 0.856
popZ
Hypothetical protein; Identified by Glimmer2; putative.
      
 0.819
Your Current Organism:
Caulobacter vibrioides CB15
NCBI taxonomy Id: 190650
Other names: C. vibrioides CB15, Caulobacter crescentus CB15, Caulobacter vibrioides ATCC 19089
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.