node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CC_0393 | CC_2100 | CC_0393 | CC_2100 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 0.916 |
CC_0393 | CC_3635 | CC_0393 | CC_3635 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.954 |
CC_0393 | IlvH | CC_0393 | CC_2101 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.996 |
CC_0393 | leuB | CC_0393 | CC_0193 | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.950 |
CC_2100 | CC_0393 | CC_2100 | CC_0393 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 0.916 |
CC_2100 | CC_3635 | CC_2100 | CC_3635 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.954 |
CC_2100 | IlvH | CC_2100 | CC_2101 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.999 |
CC_2100 | leuB | CC_2100 | CC_0193 | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.989 |
CC_3108 | CC_3635 | CC_3108 | CC_3635 | L-serine dehydratase; Identified by match to TIGR protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.930 |
CC_3108 | glyA | CC_3108 | CC_1357 | L-serine dehydratase; Identified by match to TIGR protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
CC_3108 | trpB | CC_3108 | CC_3544 | L-serine dehydratase; Identified by match to TIGR protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
CC_3399 | CC_3635 | CC_3399 | CC_3635 | Threonine synthase; Identified by match to TIGR protein family HMM TIGR00260. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.960 |
CC_3399 | IlvH | CC_3399 | CC_2101 | Threonine synthase; Identified by match to TIGR protein family HMM TIGR00260. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.584 |
CC_3399 | leuB | CC_3399 | CC_0193 | Threonine synthase; Identified by match to TIGR protein family HMM TIGR00260. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.611 |
CC_3635 | CC_0393 | CC_3635 | CC_0393 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Thiamine-pyrophosphate-requiring enzyme; Identified by match to protein family HMM. | 0.954 |
CC_3635 | CC_2100 | CC_3635 | CC_2100 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase, large subunit; Identified by match to TIGR protein family HMM TIGR00118. | 0.954 |
CC_3635 | CC_3108 | CC_3635 | CC_3108 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-serine dehydratase; Identified by match to TIGR protein family HMM TIGR00720; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.930 |
CC_3635 | CC_3399 | CC_3635 | CC_3399 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Threonine synthase; Identified by match to TIGR protein family HMM TIGR00260. | 0.960 |
CC_3635 | IlvH | CC_3635 | CC_2101 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase, small subunit; Identified by match to TIGR protein family HMM TIGR00119. | 0.961 |
CC_3635 | glyA | CC_3635 | CC_1357 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |