node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CC_1071 | hisA | CC_1071 | CC_3736 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | 0.839 |
CC_1071 | hisB | CC_1071 | CC_3734 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475. | 0.992 |
CC_1071 | hisC1 | CC_1071 | CC_2223 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.928 |
CC_1071 | hisC2 | CC_1071 | CC_2534 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.927 |
CC_1071 | hisD | CC_1071 | CC_2346 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.930 |
CC_1071 | hisE | CC_1071 | CC_3738 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503. | 0.769 |
CC_1071 | hisF | CC_1071 | CC_3737 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.898 |
CC_1071 | hisG | CC_1071 | CC_3511 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.836 |
CC_1071 | hisH | CC_1071 | CC_3735 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.904 |
CC_1071 | hisI | CC_1071 | CC_0457 | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.899 |
hisA | CC_1071 | CC_3736 | CC_1071 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | Histidinol-phosphate aminotransferase, putative; Identified by match to protein family HMM. | 0.839 |
hisA | hisB | CC_3736 | CC_3734 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | Imidazoleglycerol-phosphate dehydratase; Identified by match to PFAM protein family HMM PF00475. | 0.999 |
hisA | hisC1 | CC_3736 | CC_2223 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.831 |
hisA | hisC2 | CC_3736 | CC_2534 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.840 |
hisA | hisD | CC_3736 | CC_2346 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisE | CC_3736 | CC_3738 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | phosphoribosyl-ATP pyrophosphatase; Identified by match to PFAM protein family HMM PF01503. | 0.998 |
hisA | hisF | CC_3736 | CC_3737 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | hisF protein (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | CC_3736 | CC_3511 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.991 |
hisA | hisH | CC_3736 | CC_3735 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | CC_3736 | CC_0457 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to TIGR protein family HMM TIGR00007. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |