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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AIR96522.1ATP-dependent DNA ligase. (326 aa)    
Predicted Functional Partners:
AIS00523.1
DNA polymerase LigD, polymerase domain-containing protein.
  
 0.998
AIS01410.1
DNA polymerase LigD, polymerase domain-containing protein.
  
 0.998
AIS01546.1
Hypothetical protein.
   
 0.981
dnaN
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.966
ku
Secreted protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.937
ku-2
Putative DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.937
AIR96599.1
PHP domain-containing protein.
  
 0.925
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.888
AIR99684.1
DNA polymerase III subunit delta'.
   
 0.793
AIR96523.1
Secreted protein.
       0.752
Your Current Organism:
Streptomyces glaucescens
NCBI taxonomy Id: 1907
Other names: ATCC 19761, ATCC 23622, Actinomyces glaucescens, BCRC 11478, CBS 499.68, CCRC 11478, CCRC:11478, CECT 3133, DSM 40155, IFO 12774, IMET 43584, INA 8731, ISP 5155, JCM 4377, LMG 19330, LMG:19330, NBRC 12774, NCIMB 9619, NCIMB 9844, NRRL B-2706, NRRL-ISP 5155, S. glaucescens, UNIQEM 147, VKM Ac-617
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