STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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Coexpression
Experiments
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[Homology]
Score
tcmNMultifunctional cyclase-dehydratase-3-O-methyl transferase TcmN; The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomycin D3 (Tcm D3) to yield Tcm B3. Catalyzes as well the following side reactions: methylation of 8-O-methyl-Tcm D3 to yield Tcm E; and of 9- carboxymethyl-Tcm B3 to yield Tcm A2. (494 aa)    
Predicted Functional Partners:
tcmM
Protein of unknown function, TcmM; Acyl carrier protein.
    
  0.976
tcmO
Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO.
 
  
 
0.965
tcmK
Tetracenomycin C polyketide putative beta-ketoacyl synthase 1.
    
  0.954
tcmL
Tetracenomycin C polyketide putative beta-ketoacyl synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
    
  0.954
tcmH
Tetracenomycin polyketide synthesis hydroxylase TcmH; Oxygenase required for conversion of tetracenomycin F1 to tetracenomycin D3.
    
  0.944
tcmP
Tetracenomycin polyketide synthesis O-methyltransferase TcmP; O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions: methylation of 8-O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 to 9-carboxymethyl-TCM B3.
  
  
  0.912
AIS01729.1
Putative beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
     
  0.900
AIS01730.1
Putative tetracenomycin C polyketide putative beta-ketoacyl synthase 1; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
     
  0.900
tcmJ
Tetracenomycin polyketide synthesis protein TcmJ, putative B-ring cyclase; Possibly required for conversion of tetracenomycin F2 to tetracenomycin D3.
     0.689
tcmG
Tetracenomycin polyketide synthesis hydroxylase TcmG; Hydroxylates tetracenomycin A2 at positions C-4, C-4A, and C12A to give tetracenomycin C (TCM C). Hydroxylates as well 9- carboxymethyl-TCM B3 to yield 8-demethyl-TMC C, a side reaction.
 
     0.622
Your Current Organism:
Streptomyces glaucescens
NCBI taxonomy Id: 1907
Other names: ATCC 19761, ATCC 23622, Actinomyces glaucescens, BCRC 11478, CBS 499.68, CCRC 11478, CCRC:11478, CECT 3133, DSM 40155, IFO 12774, IMET 43584, INA 8731, ISP 5155, JCM 4377, LMG 19330, LMG:19330, NBRC 12774, NCIMB 9619, NCIMB 9844, NRRL B-2706, NRRL-ISP 5155, S. glaucescens, UNIQEM 147, VKM Ac-617
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