STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEK20812.1Carbonic anhydrase. (175 aa)    
Predicted Functional Partners:
SEK56111.1
Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily.
   
 0.971
SEK79953.1
Formate/nitrite transporter.
  
  
 0.938
SEK20738.1
Acetolactate synthase, large subunit.
  
    0.799
SEK20772.1
Acetolactate synthase, small subunit.
       0.797
SEK79538.1
Cytosine deaminase.
  
 
 0.795
hpt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
 
  
 0.774
msrA
Peptide methionine sulfoxide reductase msrA/msrB; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
       0.692
SEK20702.1
Uncharacterized membrane protein.
 
     0.613
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
 0.568
SEK20667.1
Zinc-ribbon domain-containing protein.
       0.546
Your Current Organism:
Methanobrevibacter gottschalkii
NCBI taxonomy Id: 190974
Other names: DSM 11977, M. gottschalkii, Methanobrevibacter gottschalkii Miller and Lin 2002, OCM 813, strain HO
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