STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purQUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (226 aa)    
Predicted Functional Partners:
purL
Unannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...]
 
 0.999
yexA
Unannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...]
 
 
 0.999
purM
Unannotated protein.
 
 0.996
purD
Unannotated protein; Belongs to the GARS family.
 
 
 0.988
purF
Unannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
  
 0.987
purK
Unannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
 
 0.984
purE
Unannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.978
purN
Unannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
  
 0.974
purH
Unannotated protein.
 
  
 0.970
purC
Unannotated protein; Belongs to the SAICAR synthetase family.
  
  
 0.938
Your Current Organism:
Streptomyces griseus
NCBI taxonomy Id: 1911
Other names: ATCC 23345, ATCC 23921, ATCC 25497 [[Streptomyces setonii]], ATCC 27732 [[Streptomyces cavourensis subsp. washingtonensis]], Actinomyces griseus, Actinomyces setonii, BCRC 13478, CBS 105.27 [[Streptomyces setonii]], CBS 905.68, CBS 957.69 [[Streptomyces setonii]], CCRC 13478, CCRC:13478, CCT 4836, CCUG 11104, CECT 3330, CFBP 4546, CFBP 4549 [[Streptomyces setonii]], CIP 105124, CIP 105279 [[Streptomyces setonii]], DSM 40236, DSM 40395 [[Streptomyces setonii]], DSM 41423 [[Streptomyces cavourensis subsp. washingtonensis]], HAMBI 2315, ICMP 12543 [[Streptomyces setonii]], IFO 12875, IFO 13085 [[Streptomyces setonii]], IFO 15391 [[Streptomyces cavourensis subsp. washingtonensis]], IFO 15744, ISP 5236, JCM 4047, JCM 4226 [[Streptomyces setonii]], JCM 4516 [[Streptomyces setonii]], JCM 4644, JCM 4967 [[Streptomyces cavourensis subsp. washingtonensis]], KACC 20084, KCC S-0967 [[Streptomyces cavourensis subsp. washingtonensis]], KCTC 9080, KCTC 9135, KCTC 9144 [[Streptomyces setonii]], LMG 19302, LMG:19302, NBRC 12875, NBRC 13085 [[Streptomyces setonii]], NBRC 15391 [[Streptomyces cavourensis subsp. washingtonensis]], NBRC 15744, NCIMB 13023, NCTC 13033, NRRL B-2555 [[Streptomyces setonii]], NRRL B-2682, NRRL B-8030 [[Streptomyces cavourensis subsp. washingtonensis]], NRRL-ISP 5236, NRRL-ISP 5395 [[Streptomyces setonii]], PCM 2331, S. griseus, Streptomyces cavourensis subsp. washingtonensis, Streptomyces setonii, Streptomyces sp. AP19-1, Streptomyces sp. AP19-2, Streptomyces sp. DSM 40932, Streptomyces sp. WXC19-1, VKM Ac-800, strain AUW-83 [[Streptomyces cavourensis subsp. washingtonensis]]
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.