node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
OJF68544.1 | OJF69602.1 | BK026_06940 | BK026_12850 | Beta-ketoacyl-[acyl-carrier-protein] synthase I; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.775 |
OJF69169.1 | OJF69602.1 | BK026_10375 | BK026_12850 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.824 |
OJF69169.1 | gcvT | BK026_10375 | BK026_09395 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.953 |
OJF69169.1 | glyA | BK026_10375 | BK026_07640 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
OJF69169.1 | purH | BK026_10375 | BK026_13925 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.942 |
OJF69169.1 | thyA | BK026_10375 | BK026_17295 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.408 |
OJF69602.1 | OJF68544.1 | BK026_12850 | BK026_06940 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Beta-ketoacyl-[acyl-carrier-protein] synthase I; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.775 |
OJF69602.1 | OJF69169.1 | BK026_12850 | BK026_10375 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.824 |
OJF69602.1 | OJF70369.1 | BK026_12850 | BK026_17185 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.811 |
OJF69602.1 | OJF71041.1 | BK026_12850 | BK026_17700 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.810 |
OJF69602.1 | fmt | BK026_12850 | BK026_14735 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.809 |
OJF69602.1 | gcvT | BK026_12850 | BK026_09395 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.818 |
OJF69602.1 | glyA | BK026_12850 | BK026_07640 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.773 |
OJF69602.1 | purH | BK026_12850 | BK026_13925 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.809 |
OJF69602.1 | purN | BK026_12850 | BK026_05420 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.819 |
OJF69602.1 | thyA | BK026_12850 | BK026_17295 | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.810 |
OJF70369.1 | OJF69602.1 | BK026_17185 | BK026_12850 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydromonapterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.811 |
OJF70369.1 | fmt | BK026_17185 | BK026_14735 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.976 |
OJF70369.1 | gcvT | BK026_17185 | BK026_09395 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. | 0.968 |
OJF70369.1 | glyA | BK026_17185 | BK026_07640 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |