STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Coexpression
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[Homology]
Score
hppAPyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. (801 aa)    
Predicted Functional Partners:
ANS66922.1
Small secreted protein.
       0.719
ANS66920.1
Anti-sigma factor.
       0.703
ANS66923.1
Transferase; Belongs to the methyltransferase superfamily.
       0.670
ANS66919.1
anti-sigma-B factor antagonist; Belongs to the anti-sigma-factor antagonist family.
       0.646
ANS66918.1
ATP-dependent RNA helicase.
       0.616
ANS66925.1
Hypothetical protein.
       0.593
topA
DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.579
ANS65105.1
Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.
 
   
 0.454
ANS70142.1
Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.
 
   
 0.453
ANS63966.1
uroporphyrin-III methyltransferase; Belongs to the precorrin methyltransferase family.
      
 0.433
Your Current Organism:
Streptomyces lincolnensis
NCBI taxonomy Id: 1915
Other names: ATCC 25466, BCRC 11173, CBS 630.70, CBS 699.69, CCRC 11173, CCRC:11173, DSM 2013, DSM 40355, IFO 13054, ISP 5355, JCM 4287, JCM 4488, KCTC 9088, KCTC 9089, NBRC 13054, NCIMB 9413, NRRL 2936, NRRL-ISP 5355, S. lincolnensis, VKM Ac-727
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