APO87731.1 protein (Marivivens sp. JLT3646) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

APO87731.1

3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)

Predicted Functional Partners:

APO85681.1

0.998

APO86408.1

0.954

APO85680.1

0.904

APO87732.1

0.884

APO85685.1

0.818

APO85682.1

0.817

APO85683.1

0.779

APO87730.1

0.756

APO87733.1

0.694

APO85679.1

0.692

Your Current Organism:

Marivivens sp. JLT3646

NCBI taxonomy Id: 1920883
Other names: M. sp. JLT3646, Marivivens sp. CGMCC 1.15778

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APO85679.1	APO85680.1	BSK21_00705	BSK21_00710	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
APO85679.1	APO85681.1	BSK21_00705	BSK21_00715	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
APO85679.1	APO85682.1	BSK21_00705	BSK21_00720	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protocatechuate 3,4-dioxygenase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
APO85679.1	APO85683.1	BSK21_00705	BSK21_00725	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protocatechuate 3,4-dioxygenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
APO85679.1	APO85685.1	BSK21_00705	BSK21_00735	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.779
APO85679.1	APO87731.1	BSK21_00705	BSK21_12240	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.692
APO85680.1	APO85679.1	BSK21_00710	BSK21_00705	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
APO85680.1	APO85681.1	BSK21_00710	BSK21_00715	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
APO85680.1	APO85682.1	BSK21_00710	BSK21_00720	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protocatechuate 3,4-dioxygenase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.962
APO85680.1	APO85683.1	BSK21_00710	BSK21_00725	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protocatechuate 3,4-dioxygenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.956
APO85680.1	APO85685.1	BSK21_00710	BSK21_00735	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.809
APO85680.1	APO86408.1	BSK21_00710	BSK21_04730	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.954
APO85680.1	APO87731.1	BSK21_00710	BSK21_12240	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
APO85680.1	APO87732.1	BSK21_00710	BSK21_12245	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.500
APO85681.1	APO85679.1	BSK21_00715	BSK21_00705	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	4-hydroxybenzoate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
APO85681.1	APO85680.1	BSK21_00715	BSK21_00710	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
APO85681.1	APO85682.1	BSK21_00715	BSK21_00720	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protocatechuate 3,4-dioxygenase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
APO85681.1	APO85683.1	BSK21_00715	BSK21_00725	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protocatechuate 3,4-dioxygenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.982
APO85681.1	APO85685.1	BSK21_00715	BSK21_00735	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
APO85681.1	APO86408.1	BSK21_00715	BSK21_04730	4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.857

expected number of edges:

11

PPI enrichment p-value:

7.43e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006520

Cellular amino acid metabolic process

7 of 187

1.19

1.33

1.74e-05

GO:0019752

Carboxylic acid metabolic process

9 of 309

1.09

1.26

1.79e-06

GO:0044283

Small molecule biosynthetic process

6 of 201

1.1

0.98

0.00056

GO:1901605

Alpha-amino acid metabolic process

5 of 139

1.18

0.97

0.0016

GO:0046394

Carboxylic acid biosynthetic process

5 of 141

1.17

0.96

0.0016

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030170

Pyridoxal phosphate binding

6 of 33

1.88

3.05

7.27e-08

GO:0004795

Threonine synthase activity

2 of 2

2.62

1.35

0.0034

GO:0016829

Lyase activity

5 of 119

1.24

1.09

0.00087

GO:0043168

Anion binding

7 of 432

0.83

0.65

0.0021

GO:0036094

Small molecule binding

7 of 513

0.76

0.56

0.0046

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1263

Mixed, incl. One carbon pool by folate, and Glycine cleavage complex

6 of 14

2.25

4.27

1.29e-09

CL:1281

Aromatic amino acid beta-eliminating lyase/threonine aldolase, and Aminotransferase, class-II, pyridoxal-phosphate binding site

4 of 5

2.52

3.3

5.33e-07

CL:988

Biosynthesis of amino acids, and Ribonucleoside monophosphate metabolic process

9 of 154

1.39

2.25

1.74e-09

CL:995

Valine, leucine and isoleucine biosynthesis, and Threonine biosynthetic process

3 of 17

1.87

1.37

0.0018

CL:1265

Glycine catabolic process, and Tetrahydrofolate interconversion

2 of 6

2.14

0.96

0.0164

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fla00260

Glycine, serine and threonine metabolism

9 of 31

2.08

6.01

6.43e-16

fla01230

Biosynthesis of amino acids

6 of 111

1.35

1.72

2.72e-06

fla00750

Vitamin B6 metabolism

2 of 6

2.14

1.39

0.0023

fla01120

Microbial metabolism in diverse environments

6 of 158

1.2

1.34

1.64e-05

fla01110

Biosynthesis of secondary metabolites

8 of 308

1.04

1.16

2.28e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

7 of 375

0.89

0.71

0.0019

GOCC:0005737

Cytoplasm

9 of 878

0.63

0.49

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0663

Pyridoxal phosphate

7 of 41

1.85

3.63

5.37e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01212

Beta-eliminating lyase

3 of 7

2.25

1.65

0.00075

PF00291

Pyridoxal-phosphate dependent enzyme

3 of 8

2.2

1.64

0.00075

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015424

Pyridoxal phosphate-dependent transferase

6 of 39

1.81

2.69

4.10e-07

IPR015421

Pyridoxal phosphate-dependent transferase, major domain

6 of 39

1.81

2.69

4.10e-07

IPR000634

Serine/threonine dehydratase, pyridoxal-phosphate-binding site

3 of 3

2.62

2.23

7.55e-05

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

5 of 35

1.78

2.21

8.45e-06

IPR036052

Tryptophan synthase beta chain-like, PALP domain superfamily

3 of 8

2.2

1.73

0.00049

(more ...)

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