API59766.1 protein (Tardibacter chloracetimidivorans)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

API59766.1

Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)

Predicted Functional Partners:

API59767.1

0.985

API59157.1

0.924

API58401.1

0.891

API58309.1

0.879

API59768.1

0.834

API60322.1

0.774

API59373.1

0.770

API59765.1

0.639

API61182.1

0.620

API59769.1

0.565

Your Current Organism:

Tardibacter chloracetimidivorans

NCBI taxonomy Id: 1921510
Other names: JJ-A5, KACC 19450, NBRC 113160, Sphingomonas sp. JJ-A5, T. chloracetimidivorans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
API58309.1	API59157.1	BSL82_02465	BSL82_07435	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
API58309.1	API59373.1	BSL82_02465	BSL82_08665	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
API58309.1	API59766.1	BSL82_02465	BSL82_10940	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.879
API58309.1	API60322.1	BSL82_02465	BSL82_14325	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
API58309.1	API61182.1	BSL82_02465	BSL82_14485	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.729
API58401.1	API59157.1	BSL82_03005	BSL82_07435	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
API58401.1	API59373.1	BSL82_03005	BSL82_08665	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
API58401.1	API59766.1	BSL82_03005	BSL82_10940	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.891
API58401.1	API60322.1	BSL82_03005	BSL82_14325	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
API58401.1	API61182.1	BSL82_03005	BSL82_14485	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.682
API59157.1	API58309.1	BSL82_07435	BSL82_02465	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
API59157.1	API58401.1	BSL82_07435	BSL82_03005	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	0.656
API59157.1	API59766.1	BSL82_07435	BSL82_10940	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
API59157.1	API59767.1	BSL82_07435	BSL82_10945	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Anthranilate 1,2-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.932
API59157.1	API60322.1	BSL82_07435	BSL82_14325	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.683
API59157.1	API61182.1	BSL82_07435	BSL82_14485	(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.620
API59373.1	API58309.1	BSL82_08665	BSL82_02465	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.964
API59373.1	API58401.1	BSL82_08665	BSL82_03005	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	0.656
API59373.1	API59766.1	BSL82_08665	BSL82_10940	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Rieske (2Fe-2S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.770
API59373.1	API60322.1	BSL82_08665	BSL82_14325	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.920

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.704

expected number of edges:

16

PPI enrichment p-value:

0.0317

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016311

Dephosphorylation

3 of 21

1.89

1.01

0.0111

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004721

Phosphoprotein phosphatase activity

3 of 20

1.91

1.15

0.0056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4096

Mixed, incl. Toll Like Receptor 5 (TLR5) Cascade, and Response to host

5 of 12

2.36

3.68

5.25e-08

CL:4098

Response to host, and Toll Like Receptor 5 (TLR5) Cascade

2 of 5

2.34

0.87

0.0259

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-975871

MyD88 cascade initiated on plasma membrane

3 of 6

2.44

2.6

1.17e-05

MAP-168176

Toll Like Receptor 5 (TLR5) Cascade

3 of 6

2.44

2.6

1.17e-05

MAP-168142

Toll Like Receptor 10 (TLR10) Cascade

3 of 6

2.44

2.6

1.17e-05

MAP-181438

Toll Like Receptor 2 (TLR2) Cascade

3 of 8

2.31

2.55

1.17e-05

MAP-168898

Toll-like Receptor Cascades

3 of 8

2.31

2.55

1.17e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13350

Tyrosine phosphatase family

2 of 2

2.74

1.05

0.0125

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR026893

Tyrosine/serine-protein phosphatase IphP-type

3 of 3

2.74

2.09

0.00015

IPR016130

Protein-tyrosine phosphatase, active site

3 of 4

2.61

2.07

0.00015

IPR029021

Protein-tyrosine phosphatase-like

3 of 8

2.31

1.79

0.00042

IPR000387

Tyrosine-specific protein phosphatases domain

2 of 3

2.56

1.04

0.0129

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