STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folKOriginal (2000) note: Cj0065c, folK, possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, len: 157 aa, similar to e.g. HPPK_BACSU 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (167 aa), fasta scores; opt: 194 z-score: 370.0 E(): 2.4e-13, 28.7% identity in 129 aa overlap. 35.6% identity to HP1036. Contains Pfam match to entry PF01288 HPPK,7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 4.10, E-value 1.1e-06; Updated (2006) note: Characterised within Bacillus subtilis and Escherichia coli, however, identity sco [...] (157 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Original (2000) note: Cj0585, folP, probable dihydropteroate synthase, len: 380 aa; simliar in C-terminus to e.g. DHPS_ECOLI dihydropteroate synthase (EC 2.5.1.15) (282 aa), fasta scores; opt: 508 z-score: 504.3 E(): 8.5e-21, 35.8% identity in 274 aa overlap. 41.6% identity to HP1232. Contains Pfam match to entry PF00809 DHPS, Dihydropteroate synthase; Updated (2006) note: Pfam domain PF00809 DHPS,Dihydropteroate synthase has now been changed to Pterin binding enzyme. Characterised within Campylobacter jejuni and Escherichia coli with acceptable identity score [...]
 
 
 0.995
folB
Putative dihydroneopterin aldolase; Original (2000) note: Cj0356c, unknown, len: 105 aa; 31.0% identity to HP1510; Updated (2006) note: Pfam domain PF02152 FolB Dihydroneopterin aldolase was identified within CDS. This enzyme catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. This was found by carrying out own Pfam search. Product modified to new family member due to motif match. No specific characterisation has been carried out yet. Putative kept within product function. Functional classification - Misc.
  
 
 0.987
folE
Original (2000) note: Cj0194, folE, GTP cyclohydrolase I, len: 190 aa; identical to, but slightly longer than, GCH1_CAMJE (179 aa), and highly similar to many e.g. GCH1_SYNY3 GTP cyclohydrolase I (EC 3.5.4.16) (234 aa), fasta scores; opt: 760 z-score: 1327.9 E(): 0,60.8% identity in 181 aa overlap. 49.7% identity to HP0928. Contains PS00859 GTP cyclohydrolase I signature 1 and Pfam match to entry PF01227 GTP_cyclohydro_I, GTP cyclohydrolase I, score 377.10, E-value 1.8e-109; Updated (2006) note: Characterised within Campylobacter jejuni and many others. Putative not added. Functional c [...]
 
  
 0.970
pabB
Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...]
 
 
 0.908
ribA
GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family.
  
 
 0.872
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
  
  
 0.800
Cj0063c
Putative ATP-binding protein; Original (2000) note: Cj0063c, probable ATP-binding protein, len: 288 aa; similar to hypothetical proteins in other flagellar operons e.g. YLXH_BACSU hypothetical 33.2 kd protein in flhF-cheB intergenic region (298 aa), fasta scores; opt: 390 z-score: 493.5 E(): 3.1e-20, 29.0% identity in 293 aa overlap, and to cell division proteins e.g. MIND_BACSU septum site-determining protein minD (268 aa), fasta scores; opt: 323 z-score: 417.6 E(): 5.3e-16,32.9% identity in 249 aa overlap. 45.7% identity to HP1034. Contains PS00017 ATP/GTP-binding site motif A (P-loo [...]
       0.799
flhF
Flagellar biosynthesis protein; Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity); Belongs to the GTP-binding SRP family.
  
    0.799
folC
Original (2000) note: Cj1088c, folC, probable folylpolyglutamate synthase/dihydrofolate synthase, len: 394 aa; similar to many e.g. FOLC_ECOLI folylpolyglutamate synthase (EC 6.3.2.17) / dihydrofolate synthase (EC 6.3.2.12) (422 aa), fasta sores; opt: 315 z-score: 360.4 E(): 8.9e-13, 30.7% identity in 313 aa overlap. 42.7% identity to HP1545. Contains Pfam match to entry PF01225 FPGS, Folylpolyglutamate synthase; Updated (2006) note: Characterised in Escherichia coli with marginal identity score. Appropriate motifs present. Putative not added to product function. Functional classificat [...]
  
 
 0.797
Cj0062c
Original (2000) note: Cj0062c, probable integral membrane protein, len: 118 aa; no Hp match. Contains two possible transmembrane domains. Functional classification - Cell envelope - Membranes, lipoproteins and porins.
  
    0.763
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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