STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (364 aa)    
Predicted Functional Partners:
lpxA
acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
 
 0.991
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
  
 0.967
lpxD
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
 
 0.965
lpxC
UDP-3-O-[3-hydroxymyristoyl] n-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
   
 0.939
kdtA
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
  
 0.907
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
  
 
 0.878
htrB
Original (2000) note: Cj1134, htrB, probable lipid A biosynthesis lauroyl acyltransferase, len: 295 aa; similar to e.g. HTRB_ECOLI lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (306 aa), fasta scores; opt: 274 z-score: 340.3 E(): 1.2e-11, 23.4% identity in 299 aa overlap. 27.9% identity to HP0280; Updated (2006) note: Pfam domain PF03279 Bacterial lipid A biosynthesis acyltransferase domain was identified within CDS. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet, so putative kept within produc [...]
 
   
 0.827
Cj0286c
Hypothetical protein Cj0286c; Original (2000) note: Cj0286c, unknown, len: 205 aa; 28.4% identity to HP0394 (252 aa). Functional classification - Conserved hypothetical proteins.
  
 
 0.825
greA
Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
  
  
 0.818
kdsB
Original (2000) note: Cj0813, kdsB, probable 3-deoxy-manno-octulosonate cytidylyltransferase, len: 239 aa; similar to e.g. KDSB_ECOLI 3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38) (247 aa), fasta scores; opt: 519 z-score: 611.2 E(): 9.6e-27, 39.7% identity in 242 aa overlap. 47.9% identity to HP0230; Updated (2006) note: Pfam domain PF02348 Cytidylyltransferase identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptable identity score, so putative not added to product function. Functional classification - Surface p [...]
 
  
 0.793
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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