node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cj0299 | panB | Cj0299 | Cj0298c | Original (2000) note: Cj0299, possible periplasmic beta-lactamase, len: 257 aa; similar to members of the class-D beta-lactamase family e.g. BLL1_PSEAE BETA-LACTAMASE LCR-1 PRECURSOR (EC 3.5.2.6) (Pseudomonas aeruginosa plasmid PMG76) (260 aa), fasta scores; opt: 423 z-score: 305.2 E(): 9.6e-10, 33.7% identity in 255 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Some characterisation work within Pseudomonas aeruginosa and Escherichia coli with marginal identity scores. Putative kept within product function. Functional classification - Antibiotic res [...] | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.689 |
Cj0299 | panC | Cj0299 | Cj0297c | Original (2000) note: Cj0299, possible periplasmic beta-lactamase, len: 257 aa; similar to members of the class-D beta-lactamase family e.g. BLL1_PSEAE BETA-LACTAMASE LCR-1 PRECURSOR (EC 3.5.2.6) (Pseudomonas aeruginosa plasmid PMG76) (260 aa), fasta scores; opt: 423 z-score: 305.2 E(): 9.6e-10, 33.7% identity in 255 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Some characterisation work within Pseudomonas aeruginosa and Escherichia coli with marginal identity scores. Putative kept within product function. Functional classification - Antibiotic res [...] | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.622 |
Cj0299 | panD | Cj0299 | Cj0296c | Original (2000) note: Cj0299, possible periplasmic beta-lactamase, len: 257 aa; similar to members of the class-D beta-lactamase family e.g. BLL1_PSEAE BETA-LACTAMASE LCR-1 PRECURSOR (EC 3.5.2.6) (Pseudomonas aeruginosa plasmid PMG76) (260 aa), fasta scores; opt: 423 z-score: 305.2 E(): 9.6e-10, 33.7% identity in 255 aa overlap. No Hp match. Contains N-terminal signal sequence; Updated (2006) note: Some characterisation work within Pseudomonas aeruginosa and Escherichia coli with marginal identity scores. Putative kept within product function. Functional classification - Antibiotic res [...] | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.697 |
dfp | panB | Cj0822 | Cj0298c | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.541 |
dfp | panC | Cj0822 | Cj0297c | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.722 |
dfp | ribD | Cj0822 | Cj1622 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Original (2000) note: Cj1622, ribD, probable riboflavin-specific deaminase, len: 336 aa; similar to e.g. RIBD_ACTPL riboflavin-specific deaminase (EC 3.5.4.-) (410 aa), fasta scores; opt: 320 z-score: 381.1 E(): 6.6e-14, 35.7% identity in 235 aa overlap, and RIBD_ECOLI riboflavin-specific deaminase (EC 3.5.4.-). (367 aa), opt: 249 z-score: 298.4 E(): 2.7e-09, 28.4% identity in 282 aa overlap. 37.9% identity to; HP1505. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminases zinc-binding region; Updated (2006) note: Characterisation has been carried o [...] | 0.518 |
guaA | ilvD | Cj1248 | Cj0013 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | 0.470 |
guaA | pabB | Cj1248 | Cj0862c | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | 0.521 |
guaA | panB | Cj1248 | Cj0298c | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.523 |
guaA | panC | Cj1248 | Cj0297c | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.523 |
guaA | ribD | Cj1248 | Cj1622 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Original (2000) note: Cj1622, ribD, probable riboflavin-specific deaminase, len: 336 aa; similar to e.g. RIBD_ACTPL riboflavin-specific deaminase (EC 3.5.4.-) (410 aa), fasta scores; opt: 320 z-score: 381.1 E(): 6.6e-14, 35.7% identity in 235 aa overlap, and RIBD_ECOLI riboflavin-specific deaminase (EC 3.5.4.-). (367 aa), opt: 249 z-score: 298.4 E(): 2.7e-09, 28.4% identity in 282 aa overlap. 37.9% identity to; HP1505. Contains Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminases zinc-binding region; Updated (2006) note: Characterisation has been carried o [...] | 0.655 |
guaA | trpD | Cj1248 | Cj0346 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.657 |
ilvD | guaA | Cj0013 | Cj1248 | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.470 |
ilvD | ilvE | Cj0013 | Cj0269c | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.963 |
ilvD | pabB | Cj0013 | Cj0862c | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | Original (2000) note: Cj0862c, pabB, probable para-aminobenzoate synthase component I, len: 594 aa; simlar to e.g. PABB_ECOLI para-aminobenzoate synthase component I (EC 4.1.3.-) (453 aa), fasta scores; opt: 541 z-score: 604.3 E(): 2.3e-26, 35.7% identity in 252 aa overlap. 39.3% identity to HP0293. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Updated (2006) note: Characterised in Escherichia coli with acceptable identity score. Putative not added to product function. Functional classification - Biosynthesis of cofactors, prosthetic groups and carrie [...] | 0.919 |
ilvD | panB | Cj0013 | Cj0298c | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.648 |
ilvD | panD | Cj0013 | Cj0296c | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.495 |
ilvD | trpD | Cj0013 | Cj0346 | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.666 |
ilvE | ilvD | Cj0269c | Cj0013 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Dihydroxy-acid dehydratase; Original (2000) note: Cj0013, ilvD, probable dihydroxy-acid dehydratase, len: 558 aa; highly similar to e.g. ILVD_ECOLI dihydroxy-acid dehydratase (EC 4.2.1.9) (605 aa), fasta scores; opt: 1091 z-score: 2191.4 E(): 0,46.9% identity in 597 aa overlap. 32.0% identity to HP1100 (6-phosphogluconate dehydratase). Contains PS00886 and PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures 1 and 2, and Pfam match to entry PF00920 ILVD_EDD, Dehydratase family, score 784.10, E-value 5.5e-232; Updated (2006) note: Characterised within Escherichia coli w [...] | 0.963 |
ilvE | panB | Cj0269c | Cj0298c | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.518 |