STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (387 aa)    
Predicted Functional Partners:
Cj1057c
Putative coiled-coil protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.
  
 0.994
fliG
Original (2000) note: Cj0319, fliG, probable flagellar motor switch protein, len: 342 aa; similar to many e.g. FLIG_ECOLI flagellar motor switch protein fliG (331 aa), fasta scores; opt: 609 z-score: 927.6 E(): 0,30.1% identity in 326 aa overlap. 61.5% identity to HP0352; Updated (2006) note: Pfam domain PF01706 FliG C-terminal domain was identified. Further supoport given to product function. Characterised within Escherichia coli with marginal identity score. Putative not added to product function. Functional classification - Surface structures; PMID:1551848, PMID:8308888, PMID:8550421.
   
   0.883
Cj0323
Hypothetical protein Cj0323; Original (2000) note: Cj0323, unknown, len: 398 aa; no Hp match; Updated (2006) note: Similar to hypothetical proteins from other bacteria. Functional classification -Unknown.
       0.816
ubiE
Ubiquinone/menaquinone biosynthesis methlytransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
  
    0.800
perR
Peroxide stress regulator; Original (2000) note: Cj0322, perR, regulator of peroxide stress regulon, len: 136 aa; similar to many members of the furR family e.g. FUR3_BACSU ferric uptake regulation protein homolog 3 (145 aa), fasta scores; opt: 258 z-score: 379.6 E(): 6.9e-14, 32.6% identity in 135 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF01475 Ferric uptake regulator family was identified within CDS. Further support given to product function. Marginal identity scores were obtained with many. Appropriate motifs present. Putative not added to product function. Functio [...]
   
   0.792
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
       0.789
Cj0327
Putative endoribonuclease L-PSP family protein; Original (2000) note: Cj0327, unknown, len: 116 aa; similar to hypothetical proteins e.g. YABJ_BACSU (125 aa),fasta scores; opt: 211 z-score: 261.9 E(): 2.5e-07, 33.0% identity in 109 aa overlap, and to e.g. UK14_HUMAN 14.5 kd translational inhibitor protein (137 aa), fasta scores; opt: 173 z-score: 249.5 E(): 1.2e-06, 29.2% identity in 106 aa overlap. No Hp ortholog. Also similar to Cj1388 (33.3% identity in 96 aa overlap). Contains Pfam match to entry PF01042 DUF10, Domain of unknown function, score 69.30, E-value 8.4e-17; Updated (2006 [...]
       0.762
ruvB
Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
   
 0.720
recN
Putative DNA repair protein; May be involved in recombinational repair of damaged DNA.
 
  
 0.719
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
    0.696
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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