STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cj0593cOriginal (2000) note: Cj0593c, probable integral membrane protein, len: 210 aa; similar to hypothetical proteins e.g. YICG_ECOLI (205 aa), fasta scores; opt: 783 z-score: 1285.7 E(): 0, 57.4% identity in 204 aa overlap. No Hp match; Updated (2006) note: Pfam domains x2 PF03458 UPF0126 domain was identified within CDS. This domain is found duplicated in bacterial membrane proteins of unknown function and contains three transmembrane helices. Also seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, [...] (210 aa)    
Predicted Functional Partners:
Cj0594c
Putative DNA/RNA non-specific endonuclease; Original (2000) note: Cj0594c, probable periplasmic protein, len: 216 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF01223 DNA/RNA non-specific endonuclease was identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. Thus, putative kept within product function. Functional classification -DNA replication, restriction/modification, recombination and repair.
  
    0.826
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
    0.805
Cj0591c
Putative lipoprotein; Original (2000) note: Cj0591c, probable lipoprotein, len: 73 aa; no Hp match. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to upstream gene Cj0592c (39.7% identity in 63 aa overlap). Functional classification - Membranes, lipoproteins and porins.
  
    0.651
Cj0599
Putative OmpA family membrane protein; Original (2000) note: Cj0599, probable periplasmic protein, len: 317 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF00691 OmpA family protein was identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity scores has been carried out yet. Putative kept within product function. Functional classification - Miscellaneous periplasmic proteins.
   
   0.619
Cj0592c
Putative periplasmic protein; Original (2000) note: Cj0592c, probable periplasmic protein, len: 144 aa; no Hp match. Contains N-terminal signal sequence. Some similarity to downstream gene Cj0591c (39.7% identity in 63 aa overlap). Functional classification - Miscellaneous periplasmic proteins.
       0.601
peb4-cbf2
Original (2000) note: Cj0596, peb4-cbf2, major antigenic peptide PEB4-cell binding factor 2, len: 273 aa; identical to CBF2_CAMJE cell binding factor 2 precursor,and TR:G451285 peb4=major antigenic peptide (34 aa). Also similar to memebers of the PPIC-parvulin family of rotamases e.g. PRTM_LACPA protease maturation protein precursor (299 aa), fasta scores; opt: 238 z-score: 303.5 E(): 1.3e-09, 31.3% identity in 240 aa overlap, and CYPD_ECOLI peptidyl-prolyl cis-trans isomerase D (623 aa),fasta scores; opt: 244 z-score: 293.9 E(): 4.5e-09, 27.1% identity in 221 aa overlap. 35.7% identit [...]
       0.548
fba
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
       0.548
Cj0876c
Putative periplasmic protein; Original (2000) note: Cj0876c, probable periplasmic protein, len: 96 aa; no Hp match. Functional classification - Miscellaneous periplasmic proteins.
   
    0.503
Cj0598
Putative membrane protein; Original (2000) note: Cj0598, probable membrane protein, len: 480 aa; no Hp match; Updated (2006) note: Four probable transmembrane helices predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins.
  
    0.406
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.