STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (208 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease; Original (2000) note: Cj0255c, probable exodeoxyribonuclease, len: 252 aa; similar to many e.g. EXOA_BACSU exodeoxyribonuclease (EC 3.1.11.2)(252 aa),fasta scores; opt: 676 z-score: 868.1 E(): 0, 40.5% identity in 259 aa overlap. 41.1% identity to HP1526. Contains Pfam match to entry PF01260 AP_endonulease1, AP endonucleases family 1, score 282.10, E-value 7.3e-81; Updated (2006) note: Pfam domain PF03372,Endonuclease/Exonuclease/phosphatase family identified within CDS. Further support given to product function. Characterised within Bacillus subtilis with accepta [...]
   
 0.967
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
 
  
 0.875
Cj0593c
Original (2000) note: Cj0593c, probable integral membrane protein, len: 210 aa; similar to hypothetical proteins e.g. YICG_ECOLI (205 aa), fasta scores; opt: 783 z-score: 1285.7 E(): 0, 57.4% identity in 204 aa overlap. No Hp match; Updated (2006) note: Pfam domains x2 PF03458 UPF0126 domain was identified within CDS. This domain is found duplicated in bacterial membrane proteins of unknown function and contains three transmembrane helices. Also seven probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Functional classification - Membranes, [...]
  
    0.805
Cj0594c
Putative DNA/RNA non-specific endonuclease; Original (2000) note: Cj0594c, probable periplasmic protein, len: 216 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF01223 DNA/RNA non-specific endonuclease was identified within CDS. Product modified to more specific family member due to motif match. No specific characterisation with acceptable identity score has been carried out yet. Thus, putative kept within product function. Functional classification -DNA replication, restriction/modification, recombination and repair.
  
    0.802
fliY
Original (2000) note: Cj0059c, fliY, probable flagellar motor switch protein, len: 280 aa; similar to e.g. TR:P74928 (EMBL:U36839) Treponema pallidum flagellar motor switch protein fliY (348 aa), fasta scores; opt: 277 z-score: 496.5 E(): 2.1e-20, 26.2% identity in 309 aa overlap. Also similar in C-terminus to FLIN_BORBU flagellar motor switch protein fliN (113 aa), fasta scores; opt: 231 z-score: 362.5 E(): 6.2e-13, 44.2% identity in 77 aa overlap. 39.7% identity to HP1030. Contains Pfam match to entry PF01052 SPOA_protein, Surface presentation of antigens (SPOA) protein, score 52.80, [...]
   
   0.769
motB
Original (2000) note: Cj0336c, motB, possible flagellar motor protein, len: 247 aa; similar to MOTB_BACSU chemotaxis motB protein (motility protein B) (261 aa), fasta scores; opt: 195 z-score: 275.7 E(): 4.2e-08, 30.7% identity in 261 aa overlap. 43.3% identity to HP0816. Contains Pfam match to entry PF00691 OmpA, OmpA family, score 28.50, E-value 5.6e-07; Updated (2006) note: One probable transmembrace helices identified by TMHMM2.0 within CDS. Some characterisation within Bacillus subtilis with marginal identity score. Putative kept within product function. Functional classification [...]
    
   0.769
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.679
Cj0599
Putative OmpA family membrane protein; Original (2000) note: Cj0599, probable periplasmic protein, len: 317 aa; no Hp match. Contains N-terminal signal sequence; Updated (2006) note: Pfam domain PF00691 OmpA family protein was identified within CDS. Also, one probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity scores has been carried out yet. Putative kept within product function. Functional classification - Miscellaneous periplasmic proteins.
   
   0.660
Cj0591c
Putative lipoprotein; Original (2000) note: Cj0591c, probable lipoprotein, len: 73 aa; no Hp match. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some similarity to upstream gene Cj0592c (39.7% identity in 63 aa overlap). Functional classification - Membranes, lipoproteins and porins.
       0.625
peb4-cbf2
Original (2000) note: Cj0596, peb4-cbf2, major antigenic peptide PEB4-cell binding factor 2, len: 273 aa; identical to CBF2_CAMJE cell binding factor 2 precursor,and TR:G451285 peb4=major antigenic peptide (34 aa). Also similar to memebers of the PPIC-parvulin family of rotamases e.g. PRTM_LACPA protease maturation protein precursor (299 aa), fasta scores; opt: 238 z-score: 303.5 E(): 1.3e-09, 31.3% identity in 240 aa overlap, and CYPD_ECOLI peptidyl-prolyl cis-trans isomerase D (623 aa),fasta scores; opt: 244 z-score: 293.9 E(): 4.5e-09, 27.1% identity in 221 aa overlap. 35.7% identit [...]
  
    0.606
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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